iPTMnet Report for Q9H9G7 (AGO3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H9G7 / AGO3_HUMAN
Protein Name Protein argonaute-3
Gene Name Name: AGO3
Synonyms:EIF2C3;
Organism Homo sapiens (Human)

PRO ID PR:Q9H9G7
DAG View
PRO Name protein argonaute-3 (human)
Definition A protein argonaute-3 that is encoded in the genome of human.
Short Label hAGO3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H9G7 (AGO3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S5 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
C345 Methylation IEDB 31844290
C353 Methylation IEDB 31844290
K356 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
C491 Methylation IEDB 31844290
K494 Ubiquitination PhosphoSitePlus
T512 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
C788 Methylation IEDB 31844290
S825 Phosphorylation PhosphoSitePlus   UniProt 23186163
S829 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 V5 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y323 C323 Biomuta DOID:363 / uterine cancer [ icgc ]
T338 P338 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y339 S339 Biomuta [ cosmic ] DOID:184 / bone cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y682 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S832 L832 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]