iPTMnet Report for Q9H992 (MARCHF7)
Protein Information
| UniProt AC / UniProt ID | Q9H992 / MARH7_HUMAN |
| Protein Name | E3 ubiquitin-protein ligase MARCHF7 |
| Gene Name | Name: MARCHF7 Synonyms:AXOT,MARCH7,RNF177; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9H992 |
| PRO Name | E3 ubiquitin-protein ligase MARCHF7 (human) |
| Definition | An E3 ubiquitin-protein ligase MARCHF7 that is encoded in the genome of human. |
| Short Label | hMARCHF7 |
| Category | organism-gene |
Q9H992 (MARCHF7) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S28 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R29 | Methylation | score1 | PhosphoSitePlus | |||
| S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T36 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S127 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S179 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S218 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S221 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S224 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| T238 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S243 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S271 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S284 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S288 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S300 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S314 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S317 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S324 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S359 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S389 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T395 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R406 | Methylation | score1 | PhosphoSitePlus | |||
| S428 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K522 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K536 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S544 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K586 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K591 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S597 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K608 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K610 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T686 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S687 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S691 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T238 | Phosphorylation | score0 | HPRD | 18077418 | ||
| S243 | Phosphorylation | score0 | HPRD | 18077418 | ||
| S245 | Phosphorylation | score0 | HPRD | 18077418 | ||
| S544 | Phosphorylation | score0 | HPRD | 19664994 | ||
| T686 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S687 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S691 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S13 | Y13 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| R29 | K29 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| T36 | A36 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K93 | E93 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S179 | L179 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S221 | Y221 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T238 | M238 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S245 | C245 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y315 | F315 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S317 | F317 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| R406 | T406 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K522 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
DAG View