iPTMnet Report for Q9H7B4 (SMYD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H7B4 / SMYD3_HUMAN
Protein Name Histone-lysine N-methyltransferase SMYD3
Gene Name Name: SMYD3
Synonyms:ZMYND1,ZNFN3A1;
Organism Homo sapiens (Human)

PRO ID PR:Q9H7B4
DAG View
PRO Name histone-lysine N-methyltransferase SMYD3 (human)
Definition A histone-lysine N-methyltransferase SMYD3 that is encoded in the genome of human.
Short Label hSMYD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H7B4 (SMYD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K5 Sumoylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus   UniProt 23186163
S33 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
T268 Phosphorylation RLIMS-P 33205017
K271 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 L33 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S33 I33 Biomuta DOID:363 / uterine cancer [ icgc ]
T268 A268 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K292 N292 Biomuta DOID:1319 / brain cancer [ cosmic ]
K391 R391 Biomuta DOID:3571 / liver cancer [ cosmic ]