iPTMnet Report for Q9H7B4 (SMYD3)
Protein Information
UniProt AC / UniProt ID | Q9H7B4 / SMYD3_HUMAN |
Protein Name | Histone-lysine N-methyltransferase SMYD3 |
Gene Name | Name: SMYD3 Synonyms:ZMYND1,ZNFN3A1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9H7B4 |
PRO Name | histone-lysine N-methyltransferase SMYD3 (human) |
Definition | A histone-lysine N-methyltransferase SMYD3 that is encoded in the genome of human. |
Short Label | hSMYD3 |
Category | organism-gene |
Q9H7B4 (SMYD3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378 | ||
K5 | Sumoylation | score1 | PhosphoSitePlus | |||
K5 | Ubiquitination | score1 | PhosphoSitePlus | |||
T22 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
K42 | Ubiquitination | score1 | PhosphoSitePlus | |||
K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y124 | Phosphorylation | score1 | PhosphoSitePlus | |||
K135 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y239 | Phosphorylation | score1 | PhosphoSitePlus | |||
T268 | Phosphorylation | score0 | RLIMS-P | 33205017 | ||
K271 | Ubiquitination | score1 | PhosphoSitePlus | |||
K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
K375 | Ubiquitination | score1 | PhosphoSitePlus | |||
K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
K391 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S33 | L33 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
S33 | I33 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T268 | A268 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K292 | N292 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
K391 | R391 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |