iPTMnet Report for Q9H3S4 (TPK1)
Protein Information
| UniProt AC / UniProt ID | Q9H3S4 / TPK1_HUMAN |
| Protein Name | Thiamin pyrophosphokinase 1 |
| Gene Name | Name: TPK1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9H3S4 |
| PRO Name | thiamin pyrophosphokinase 1 (human) |
| Definition | A thiamin pyrophosphokinase 1 that is encoded in the genome of human. |
| Short Label | hTPK1 |
| Category | organism-gene |
DAG ViewQ9H3S4 (TPK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S13 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T14 | Phosphorylation | score0 | HPRD | 20068231 | ||
| K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K111 | Acetylation | score1 | PhosphoSitePlus | |||
| K115 | Acetylation | score1 | PhosphoSitePlus | |||
| K118 | Acetylation | score1 | PhosphoSitePlus | |||
| S138 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T14 | I14 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| K111 | M111 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K111 | N111 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K118 | T118 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K118 | N118 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S138 | C138 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
