Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H3S4 / TPK1_HUMAN
Protein Name Thiamin pyrophosphokinase 1
Gene Name Name: TPK1
Organism Homo sapiens (Human)

PRO ID PR:Q9H3S4
DAG View
PRO Name thiamin pyrophosphokinase 1 (human)
Definition A thiamin pyrophosphokinase 1 that is encoded in the genome of human.
Short Label hTPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H3S4 (TPK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation HPRD 20068231
T14 Phosphorylation HPRD 20068231
K86 Ubiquitination PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation HPRD 20068231
T14 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T14 I14 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K111 M111 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K111 N111 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
K115 Q115 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S138 C138 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]