iPTMnet Report Q9H1B7 IRF2BPL

Protein Information

UniProt AC / UniProt ID	Q9H1B7 / I2BPL_HUMAN
Protein Name	Probable E3 ubiquitin-protein ligase IRF2BPL
Gene Name	Name: IRF2BPL Synonyms:C14orf4,EAP1,KIAA1865;ORFNames:My039;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9H1B7 DAG View
PRO Name	probable E3 ubiquitin-protein ligase IRF2BPL (human)
Definition	An enhanced at puberty protein 1 that is encoded in the genome of human.
Short Label	hIRF2BPL
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9H1B7 (IRF2BPL) as Substrate

Q9H1B7

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S2 S7 S8 S9 S13 Y15 S69 K79 S135 S152 S169 R170 S179 S182 S183 S184 T186 S215 S218 S219 S224 S227 T286 T302 S306 T308 S313 S314 S319 S334 S336 S337 T338 K371 K373 Y388 S397 K410 K458 K464 S519 T524 S540 S547 S553 T610 T611 S622 T633 T636 S639 S645 S657 S658 S659 S662 S665 S705 K748	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	Score Select all 1 2	Source Select all GlyGen HPRD PhosphoSitePlus UniProt phospho.ELM	PMID
S2	Phosphorylation	score1	PhosphoSitePlus
S7	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S7	Phosphorylation	score1	PhosphoSitePlus
S8	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S8	Phosphorylation	score1	PhosphoSitePlus
S9	Phosphorylation	score1	PhosphoSitePlus
S13	Phosphorylation	score1	PhosphoSitePlus
Y15	Phosphorylation	score1	PhosphoSitePlus
S69	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
K79	Ubiquitination	score1	PhosphoSitePlus
S135	Phosphorylation	score1	PhosphoSitePlus
S152	Phosphorylation	score1	PhosphoSitePlus
S169	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
R170	Methylation	score1	PhosphoSitePlus
S179	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...32938750, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S182	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S183	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S184	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 31373491, 34105348
T186	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S215	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 20068231, 24275569
S218	Phosphorylation	score1	PhosphoSitePlus
S219	Phosphorylation	score1	PhosphoSitePlus
S224	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	18669648
S227	Phosphorylation	score1	PhosphoSitePlus
T286	Phosphorylation	score1	PhosphoSitePlus
T302	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S306	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
T308	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S313	Phosphorylation	score1	phospho.ELM	15302935
S314	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S319	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S334	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	19651622, 15302935
S336	Phosphorylation	score1	PhosphoSitePlus
S337	Phosphorylation	score1	PhosphoSitePlus
T338	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	19651622, 15302935
K371	Ubiquitination	score1	PhosphoSitePlus
K373	Ubiquitination	score1	PhosphoSitePlus
Y388	Phosphorylation	score1	PhosphoSitePlus
S397	Phosphorylation	score1	PhosphoSitePlus
K410	Ubiquitination	score1	PhosphoSitePlus
K458	Acetylation	score1	PhosphoSitePlus
K458	Sumoylation	score1	PhosphoSitePlus
K458	Ubiquitination	score1	PhosphoSitePlus
K464	Ubiquitination	score1	PhosphoSitePlus
S519	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 24275569
T524	Phosphorylation	score1	PhosphoSitePlus
S540	Phosphorylation	score1	PhosphoSitePlus
S547	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 17322306, 21406692, ...23186163, 18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 24275569, 18707149, 20166139, 17287340, 19690332, 20068231, 17081983
S553	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 20068231
T610	Phosphorylation	score2	HPRD PhosphoSitePlus	18452278
T611	Phosphorylation	score2	HPRD PhosphoSitePlus	18452278
S622	Phosphorylation	score1	PhosphoSitePlus
T633	O-Glycosylation	score1	GlyGen	34105348
T636	O-Glycosylation	score1	GlyGen	34105348
S639	Phosphorylation	score2	HPRD PhosphoSitePlus UniProt	23186163, 18452278
S645	O-Glycosylation	score1	GlyGen	23301498, 34846842, 33214551, ...35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 32119511, 35289036, 29351928, 34105348
S657	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	23186163, 17081983, 18220336, ...15302935, 18452278, 19651622, 18669648, 19415658, 24275569, 20166139, 19690332, 20068231
S658	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	17081983, 18220336, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231
S659	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 21406692, 23186163, ...17081983, 18220336, 19664994, 15302935, 19664995, 18452278, 19651622, 18669648, 19415658, 24275569, 20166139, 15345747, 19690332, 20068231
S662	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 21406692, 23186163, ...16964243, 18220336, 15302935, 19664995, 18452278, 19651622, 18669648, 24275569, 19690332, 17081983
S665	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	19413330, 18669648, 17081983, ...19651622
S705	Phosphorylation	score1	PhosphoSitePlus
K748	Ubiquitination	score1	PhosphoSitePlus

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S2 S69 R170 S227 S313 S397 K410 K458 S519 S622 S658 S659 S662 S705	Variant Select all C170 F622 F69 F705 L2 L313 L397 L662 N410 N658 R659 T458 T519 Y227 Y622	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S2	L2	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S69	F69	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
R170	C170	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
S227	Y227	Biomuta	DOID:363 / uterine cancer [ icgc ]
S313	L313	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S397	L397	Biomuta	DOID:363 / uterine cancer [ icgc ]
K410	N410	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K458	T458	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S519	T519	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S622	F622	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S622	Y622	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S658	N658	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S659	R659	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S662	L662	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S705	F705	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9H1B7 (IRF2BPL)

Protein Information

Interactive Sequence View

Q9H1B7 (IRF2BPL) as Substrate

PTM sites affected in variants