Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H1B7 / I2BPL_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase IRF2BPL
Gene Name Name: IRF2BPL
Synonyms:C14orf4,EAP1,KIAA1865;ORFNames:My039;
Organism Homo sapiens (Human)

PRO ID PR:Q9H1B7
DAG View
PRO Name probable E3 ubiquitin-protein ligase IRF2BPL (human)
Definition An enhanced at puberty protein 1 that is encoded in the genome of human.
Short Label hIRF2BPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H1B7 (IRF2BPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
S69 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K79 Ubiquitination PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
R170 Methylation PhosphoSitePlus
S215 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 20068231
S218 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S227 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S313 Phosphorylation phospho.ELM 15302935
S334 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935
S336 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
T338 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935
K371 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K458 Acetylation PhosphoSitePlus
K458 Sumoylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T524 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S547 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...17287340, 18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 24275569, 18707149, 20166139, 23186163, 19690332, 20068231, 17081983
S553 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
T610 Phosphorylation HPRD   PhosphoSitePlus 18452278
T611 Phosphorylation HPRD   PhosphoSitePlus 18452278
S622 Phosphorylation PhosphoSitePlus
S639 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
S657 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 19415658, 20068231
S658 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231
S659 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18220336, 19664994, 15302935, 19664995, 18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 15345747, 19415658, 20068231
S662 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...16964243, 18220336, 15302935, 19664995, 18452278, 19651622, 18669648, 24275569, 19690332, 17081983
S665 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17081983, ...19651622
S705 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S227 Y227 Biomuta DOID:363 / uterine cancer [ tcga ]
K373 T373 Biomuta DOID:363 / uterine cancer [ tcga ]
S397 L397 Biomuta DOID:363 / uterine cancer [ tcga ]
S519 T519 Biomuta DOID:1324 / lung cancer [ cosmic ]
S622 F622 Biomuta DOID:1909 / melanoma [ tcga ]
S705 F705 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:1909 / melanoma [ tcga ]