iPTMnet Report for Q9GZV5 (WWTR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9GZV5 / WWTR1_HUMAN
Protein Name WW domain-containing transcription regulator protein 1
Gene Name Name: WWTR1
Synonyms:TAZ;
Organism Homo sapiens (Human)

PRO ID PR:Q9GZV5
DAG View
PRO Name WW domain-containing transcription regulator protein 1 (human)
Definition A WW domain-containing transcription regulator protein 1 that is encoded in the genome of human.
Short Label hWWTR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9GZV5 (WWTR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus   UniProt 23186163
S65 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S87 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus 17081983, 19651622, 18669648, ...20068231, 27869121
S89 Phosphorylation HPRD   IEDB   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 21808241, 22658639, 31848261, ...20412773, 27869121, 11118213, 18227151, 20068231
S89 Phosphorylation O95835 (LATS1) neXtProt   Signor 21808241, 20412773, 22658639
S89 Phosphorylation Q9NRM7 (LATS2) neXtProt   Signor 21808241, 22658639, 18227151
S90 Phosphorylation HPRD   IEDB   PhosphoSitePlus 17081983, 26375055, 20068231, ...26183396, 27869121
S90 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26375055, 26183396
S93 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T98 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S105 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 26375055, 26183396, ...20068231
S105 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26375055, 26183396
S117 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y118 Phosphorylation HPRD 20068231
S173 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S185 Phosphorylation IEDB   PhosphoSitePlus 27869121
C262 Methylation IEDB 31844290
T285 Phosphorylation PhosphoSitePlus 26183396
T285 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26183396
S290 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus   UniProt 18227151
T312 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   Signor 24715453
S314 Phosphorylation P48730 (CSNK1D) Signor 24715453
S314 Phosphorylation P49674 (CSNK1E) Signor 24715453
Y321 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus 26375055
T326 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26375055
T346 Phosphorylation PhosphoSitePlus 26375055
T346 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26375055
K392 Sumoylation PhosphoSitePlus
S393 Phosphorylation HPRD   PhosphoSitePlus 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049702 (hWWTR1/Phos:1) pS89 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S62 L62 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S89 T89 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S89 W89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S89 A89 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S90 P90 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T285 I285 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S307 L307 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y321 C321 Biomuta DOID:184 / bone cancer [ cosmic ]