Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9GZT9 / EGLN1_HUMAN
Protein Name Egl nine homolog 1
Gene Name Name: EGLN1
Organism Homo sapiens (Human)

DAG View
PRO Name egl nine homolog 1 (human)
Definition An egl nine homolog 1 that is encoded in the genome of human.
Short Label hEGLN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9GZT9 (EGLN1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S5 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 28199842
S14 Phosphorylation RLIMS-P 28199842
S61 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 28199842, 20068231
C127 S-Nitrosylation dbSNO 26338901
S174 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K244 Methylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K408 Acetylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S125 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C127 S127 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S174 N174 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K216 N216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T232 N232 Biomuta DOID:3571 / liver cancer [ icgc ]
K402 T402 Biomuta DOID:1612 / breast cancer [ tcga ]
K416 * Biomuta DOID:263 / kidney cancer [ icgc, tcga ]