iPTMnet Report for Q9BZE2 (PUS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZE2 / PUS3_HUMAN
Protein Name tRNA pseudouridine(38/39) synthase
Gene Name Name: PUS3
ORFNames:FKSG32;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZE2
DAG View
PRO Name tRNA pseudouridine(38/39) synthase (human)
Definition A tRNA pseudouridine synthase 3 that is encoded in the genome of human.
Short Label hPUS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZE2 (PUS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K13 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
Y314 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
T456 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T462 Phosphorylation PhosphoSitePlus
T466 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T468 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T475 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K99 N99 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T456 K456 Biomuta DOID:3571 / liver cancer [ cosmic ]
T468 M468 Biomuta [ cosmic ]
T468 S468 Biomuta [ cosmic ]