iPTMnet Report for Q9BZE2 (PUS3)
Protein Information
UniProt AC / UniProt ID | Q9BZE2 / PUS3_HUMAN |
Protein Name | tRNA pseudouridine(38/39) synthase |
Gene Name | Name: PUS3 ORFNames:FKSG32; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9BZE2 |
PRO Name | tRNA pseudouridine(38/39) synthase (human) |
Definition | A tRNA pseudouridine synthase 3 that is encoded in the genome of human. |
Short Label | hPUS3 |
Category | organism-gene |
Q9BZE2 (PUS3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330 | ||
K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
S142 | Phosphorylation | score1 | PhosphoSitePlus | |||
K227 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y314 | Phosphorylation | score1 | PhosphoSitePlus | |||
S315 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y325 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y411 | Phosphorylation | score1 | PhosphoSitePlus | |||
T456 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
T462 | Phosphorylation | score1 | PhosphoSitePlus | |||
T466 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
T468 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
T475 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K99 | N99 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T456 | K456 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T468 | M468 | Biomuta | [ cosmic ] | |
T468 | S468 | Biomuta | [ cosmic ] |