iPTMnet Report Q9BY41 HDAC8

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9BY41 / HDAC8_HUMAN
Protein Name	Histone deacetylase 8
Gene Name	Name: HDAC8 Synonyms:HDACL1;ORFNames:CDA07;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9BY41 DAG View
PRO Name	histone deacetylase 8 (human)
Definition	A histone deacetylase 8 that is encoded in the genome of human.
Short Label	hHDAC8
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9BY41 (HDAC8) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S39	Phosphorylation	P17612 (PRKACA)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	29716651, 14701748, 15242608, ...24171457
	S43	Phosphorylation		score1	PhosphoSitePlus
	Y48	Phosphorylation		score1	PhosphoSitePlus
	S63	Phosphorylation		score1	PhosphoSitePlus
	K221	Ubiquitination		score1	PhosphoSitePlus
	C244	Methylation		score1	IEDB	31844290
	Y252	Phosphorylation		score1	PhosphoSitePlus
	K370	Ubiquitination		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S39	Phosphorylation	P17612 (PRKACA)	score1	HPRD	14701748

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K239	Ubiquitination		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K122	Ubiquitination		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S43	F43	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S43	Y43	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]