iPTMnet Report for Q9BY41 (HDAC8)
Protein Information
| UniProt AC / UniProt ID | Q9BY41 / HDAC8_HUMAN |
| Protein Name | Histone deacetylase 8 |
| Gene Name | Name: HDAC8 Synonyms:HDACL1;ORFNames:CDA07; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9BY41 |
| PRO Name | histone deacetylase 8 (human) |
| Definition | A histone deacetylase 8 that is encoded in the genome of human. |
| Short Label | hHDAC8 |
| Category | organism-gene |
DAG ViewQ9BY41 (HDAC8) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S39 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 29716651, 14701748, 15242608, ... | ||
| S39 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt PhosphoSitePlus Signor | 14701748 | |
| S43 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C244 | Methylation | score1 | IEDB | 31844290 | ||
| Y252 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K370 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S39 | Phosphorylation | score1 | HPRD | 14701748 | ||
| S39 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 14701748 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K239 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K122 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S43 | F43 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S43 | Y43 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
