iPTMnet Report Q9BXM7 PINK1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9BXM7 / PINK1_HUMAN
Protein Name	Serine/threonine-protein kinase PINK1, mitochondrial precursor
Gene Name	Name: PINK1
Organism	Homo sapiens (Human)

PRO ID	PR:Q9BXM7 DAG View
PRO Name	serine/threonine-protein kinase PINK1, mitochondrial (human)
Definition	A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human.
Short Label	hPINK1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9BXM7 (PINK1) as Substrate

Q9BXM7

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K137	Ubiquitination		score1	PhosphoSitePlus
	K164	Ubiquitination		score1	PhosphoSitePlus
	K186	Ubiquitination		score1	PhosphoSitePlus
	S228	Phosphorylation	Q9BXM7 (PINK1)	score4	PhosphoSitePlus RLIMS-P UniProt	22910362, 28438176, 35042401, ...25527497
	S229	Phosphorylation		score0	RLIMS-P	22910362
	S230	Phosphorylation		score0	RLIMS-P	22910362
	T257	Phosphorylation	Q9BXM7 (PINK1)	score4	PhosphoSitePlus RLIMS-P	24660806, 24962176, 22724072
	K262	Acetylation		score1	PhosphoSitePlus
	S284	Phosphorylation		score1	PhosphoSitePlus
	T313	Phosphorylation	Q7KZI7 (MARK2)	score3	neXtProt PhosphoSitePlus	22238344
	K319	Ubiquitination		score1	PhosphoSitePlus
	S402	Phosphorylation	Q9BXM7 (PINK1)	score4	PhosphoSitePlus RLIMS-P UniProt	22910362, 28438176, 25527497
	K433	Ubiquitination		score1	PhosphoSitePlus
	S465	Phosphorylation		score0	RLIMS-P	29255601
	S495	Phosphorylation		score1	PhosphoSitePlus
	K547	Ubiquitination		score1	PhosphoSitePlus

Q9BXM7 (PINK1) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O15379 (HDAC3)	S424	score2	RLIMS-P+	25305081
	O43464 (HTRA2)	S142	score1	Signor	17906618
	O60260 (PRKN)	S65	score4	PhosphoSitePlus Signor	24660806, 23754282, 22724072, ...26161729
	P0CG48 (UBC)	S65	score1	Signor	24784582
	Q8IXI2 (RHOT1)	S156	score2	PhosphoSitePlus	22078885
	Q9BXM7 (PINK1)	S228	score3	PhosphoSitePlus UniProt	22910362
	Q9BXM7 (PINK1)	T257	score2	PhosphoSitePlus	22724072
	Q9BXM7 (PINK1)	S402	score3	PhosphoSitePlus UniProt	22910362
	Q9Y2N7 (HIF3A)	T12	score3	RLIMS-P+ Signor	27551449

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K137	N137	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
K319	N319	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
K547	T547	Biomuta		DOID:10283 / prostate cancer [ cosmic ]