Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9BXM7 / PINK1_HUMAN
Protein Name Serine/threonine-protein kinase PINK1, mitochondrial precursor
Gene Name Name: PINK1
Organism Homo sapiens (Human)

DAG View
PRO Name serine/threonine-protein kinase PINK1, mitochondrial (human)
Definition A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human.
Short Label hPINK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9BXM7 (PINK1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K137 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22910362, 28438176, 27807026, ...25527497
S228 Phosphorylation Q9BXM7 (PINK1) PhosphoSitePlus   UniProt 22910362
S229 Phosphorylation RLIMS-P 22910362
S230 Phosphorylation RLIMS-P 22910362
T257 Phosphorylation PhosphoSitePlus   RLIMS-P 24660806, 24962176, 22724072
T257 Phosphorylation Q9BXM7 (PINK1) PhosphoSitePlus 22724072
K262 Acetylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T313 Phosphorylation neXtProt   PhosphoSitePlus 22238344
T313 Phosphorylation Q7KZI7 (MARK2) neXtProt   PhosphoSitePlus 22238344
K319 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22910362, 28438176, 27807026, ...25527497
S402 Phosphorylation Q9BXM7 (PINK1) PhosphoSitePlus   UniProt 22910362
K433 Ubiquitination PhosphoSitePlus
S465 Phosphorylation RLIMS-P 29255601
S495 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus

Q9BXM7 (PINK1) as PTM Enzyme

Substrate Site Score Source PMID
O15379 (HDAC3) S424 RLIMS-P+ 25305081
O43464 (HTRA2) S142 Signor 17906618
O60260 (PRKN) S65 PhosphoSitePlus   Signor 24660806, 23754282, 22724072, ...26161729
P0CG48 (UBC) S65 Signor 24784582
Q8IXI2 (RHOT1) S156 PhosphoSitePlus 22078885
Q9BXM7 (PINK1) S228 PhosphoSitePlus   UniProt 22910362
Q9BXM7 (PINK1) T257 PhosphoSitePlus 22724072
Q9BXM7 (PINK1) S402 PhosphoSitePlus   UniProt 22910362
Q9Y2N7 (HIF3A) T12 RLIMS-P+   Signor 27551449

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K137 N137 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T257 I257 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K547 T547 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]