iPTMnet Report for Q9BXM7 (PINK1)
Protein Information
| UniProt AC / UniProt ID | Q9BXM7 / PINK1_HUMAN |
| Protein Name | Serine/threonine-protein kinase PINK1, mitochondrial precursor |
| Gene Name | Name: PINK1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9BXM7 |
| PRO Name | serine/threonine-protein kinase PINK1, mitochondrial (human) |
| Definition | A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human. |
| Short Label | hPINK1 |
| Category | organism-gene |
DAG ViewQ9BXM7 (PINK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S228 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22910362, 28438176, 35042401, ... | ||
| S228 | Phosphorylation | Q9BXM7 (PINK1) | score3 | PhosphoSitePlus UniProt | 22910362 | |
| S229 | Phosphorylation | score0 | RLIMS-P | 22910362 | ||
| S230 | Phosphorylation | score0 | RLIMS-P | 22910362 | ||
| T257 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 24660806, 24962176, 22724072 | ||
| T257 | Phosphorylation | Q9BXM7 (PINK1) | score2 | PhosphoSitePlus | 22724072 | |
| K262 | Acetylation | score1 | PhosphoSitePlus | |||
| S284 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T313 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 22238344 | ||
| T313 | Phosphorylation | Q7KZI7 (MARK2) | score3 | neXtProt PhosphoSitePlus | 22238344 | |
| K319 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S402 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22910362, 28438176, 25527497 | ||
| S402 | Phosphorylation | Q9BXM7 (PINK1) | score3 | PhosphoSitePlus UniProt | 22910362 | |
| K433 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S465 | Phosphorylation | score0 | RLIMS-P | 29255601 | ||
| S495 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K547 | Ubiquitination | score1 | PhosphoSitePlus |
Q9BXM7 (PINK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O15379 (HDAC3) | S424 | score2 | RLIMS-P+ | 25305081 | |
| O43464 (HTRA2) | S142 | score1 | Signor | 17906618 | |
| O60260 (PRKN) | S65 | score4 | PhosphoSitePlus Signor | 24660806, 23754282, 22724072, ... | |
| P0CG48 (UBC) | S65 | score1 | Signor | 24784582 | |
| Q8IXI2 (RHOT1) | S156 | score2 | PhosphoSitePlus | 22078885 | |
| Q9BXM7 (PINK1) | S228 | score3 | PhosphoSitePlus UniProt | 22910362 | |
| Q9BXM7 (PINK1) | T257 | score2 | PhosphoSitePlus | 22724072 | |
| Q9BXM7 (PINK1) | S402 | score3 | PhosphoSitePlus UniProt | 22910362 | |
| Q9Y2N7 (HIF3A) | T12 | score3 | RLIMS-P+ Signor | 27551449 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K137 | N137 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| K319 | N319 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K547 | T547 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] |
 |