Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BV57 / MTND_HUMAN
Protein Name 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Gene Name Name: ADI1
Synonyms:MTCBP1;ORFNames:HMFT1638;
Organism Homo sapiens (Human)

PRO ID PR:Q9BV57
DAG View
PRO Name 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (human)
Definition A 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase that is encoded in the genome of human.
Short Label hADI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BV57 (ADI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R32 Methylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K54 N54 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y104 H104 Biomuta DOID:10534 / stomach cancer [ tcga ]
K144 E144 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]