iPTMnet Report for Q9BUB5 (MKNK1)
Protein Information
| UniProt AC / UniProt ID | Q9BUB5 / MKNK1_HUMAN |
| Protein Name | MAP kinase-interacting serine/threonine-protein kinase 1 |
| Gene Name | Name: MKNK1 Synonyms:MNK1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9BUB5 |
| PRO Name | MAP kinase-interacting serine/threonine-protein kinase 1 (human) |
| Definition | A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. |
| Short Label | hMKNK1 |
| Category | organism-gene |
DAG ViewQ9BUB5 (MKNK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S39 | Phosphorylation | score4 | HPRD neXtProt PhosphoSitePlus Signor UniProt | 15234964, 23186163 | ||
| S39 | Phosphorylation | Q13177 (PAK2) | score3 | HPRD neXtProt Signor | 15234964 | |
| Y60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S191 | Phosphorylation | score1 | HPRD | 16162500 | ||
| S221 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S226 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S237 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T250 | Phosphorylation | score4 | HPRD IntAct neXtProt PRO PhosphoSitePlus Signor UniProt | 11463832, 17590453, 20927323, ... | ||
| T250 | Phosphorylation | Q16539 (MAPK14) | score4 | neXtProt PhosphoSitePlus Signor | 17590453, 9155017 | |
| T255 | Phosphorylation | score4 | HPRD IntAct neXtProt PRO PhosphoSitePlus Signor UniProt | 17130135, 11463832, 17590453, ... | ||
| T255 | Phosphorylation | P28482 (MAPK1) | score2 | PhosphoSitePlus | 17130135 | |
| T255 | Phosphorylation | Q16539 (MAPK14) | score4 | neXtProt PhosphoSitePlus Signor | 17130135, 17590453, 9155017 | |
| K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K353 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T385 | Phosphorylation | score4 | HPRD neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt | 9155018, 11463832, 23186163 | ||
| T385 | Phosphorylation | P27361 (MAPK3) | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus Signor | 9155018 | |
| S393 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S413 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S437 | Phosphorylation | score3 | HPRD PRO PhosphoSitePlus | 16162500 | ||
| R455 | Methylation | score1 | PhosphoSitePlus | |||
| R459 | Methylation | score1 | PhosphoSitePlus | |||
| S460 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T209 | Phosphorylation | score2 | PhosphoSitePlus | 17590453 | ||
| T209 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 17590453 | |
| T214 | Phosphorylation | score2 | PhosphoSitePlus | 17590453 | ||
| T214 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 17590453 | |
| S353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S372 | Phosphorylation | score1 | PhosphoSitePlus |
Q9BUB5 (MKNK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O43597 (SPRY2) | S112 | score4 | PhosphoSitePlus Signor | 16479008, 19864419 | |
| O43597 (SPRY2) | S121 | score4 | PhosphoSitePlus Signor | 16479008, 19864419 | |
| P06730 (EIF4E) | S209 | score4 | HPRD PhosphoSitePlus RLIMS-P+ Signor | 17130135, 11463832, 17590453, ... | |
| P09651 (HNRNPA1) | S192 | score2 | PhosphoSitePlus | 16111636 | |
| P09651 (HNRNPA1) | S362 | score2 | PhosphoSitePlus | 16111636 | |
| P09651 (HNRNPA1) | S363 | score2 | PhosphoSitePlus | 16111636 | |
| P09651 (HNRNPA1) | S364 | score2 | PhosphoSitePlus | 16111636 | |
| P23246 (SFPQ) | S8 | score2 | PhosphoSitePlus | 17965020 | |
| P23246 (SFPQ) | S283 | score2 | PhosphoSitePlus | 17965020 | |
| P47712 (PLA2G4A) | S727 | score3 | HPRD Signor | 16964243, 19664994, 18669648, ... | |
| Q9NP80 (PNPLA8) | S511 | score2 | PhosphoSitePlus | 23258543 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048383 (hMKNK1/Phos:1) | pT250,pT255,pT385,pS437 | PRO |
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