Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BUB5 / MKNK1_HUMAN
Protein Name MAP kinase-interacting serine/threonine-protein kinase 1
Gene Name Name: MKNK1
Synonyms:MNK1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BUB5
DAG View
PRO Name MAP kinase-interacting serine/threonine-protein kinase 1 (human)
Definition A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.
Short Label hMKNK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BUB5 (MKNK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 15234964, 23186163
Y60 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S191 Phosphorylation HPRD 16162500
S221 Phosphorylation PhosphoSitePlus   UniProt 23186163
S226 Phosphorylation PhosphoSitePlus   UniProt 23186163
S237 Phosphorylation PhosphoSitePlus
T250 Phosphorylation Q16539 (MAPK14) HPRD   IntAct   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 11463832, 17590453, 20927323, ...15350534, 11154262, 9155017
T255 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) HPRD   IntAct   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 17130135, 11463832, 17590453, ...20927323, 15350534, 11154262, 9155017
K332 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
T385 Phosphorylation P27361 (MAPK3) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 9155018, 11463832, 23186163
S393 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S437 Phosphorylation HPRD   PRO   PhosphoSitePlus 16162500
R455 Methylation PhosphoSitePlus
R459 Methylation PhosphoSitePlus
S460 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
K164 Ubiquitination PhosphoSitePlus
T209 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 17590453
T214 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 17590453
S353 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus


Q9BUB5 (MKNK1) as PTM Enzyme



Substrate Site Score Source PMID
O43597 (SPRY2) S112 PhosphoSitePlus   Signor 16479008, 19864419
O43597 (SPRY2) S121 PhosphoSitePlus   Signor 16479008, 19864419
P06730-1 (EIF4E) S209 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 17130135, 11463832, 17590453, ...9878069, 20722422, 17724079, 9155017
P09651 (HNRNPA1) S192 PhosphoSitePlus 16111636
P09651 (HNRNPA1) S362 PhosphoSitePlus 16111636
P09651 (HNRNPA1) S363 PhosphoSitePlus 16111636
P09651 (HNRNPA1) S364 PhosphoSitePlus 16111636
P23246 (SFPQ) S8 PhosphoSitePlus 17965020
P23246 (SFPQ) S283 PhosphoSitePlus 17965020
P47712 (PLA2G4A) S727 HPRD   Signor 16964243, 19664994, 18669648, ...10978317, 20068231, 18212344
Q9NP80 (PNPLA8) S511 PhosphoSitePlus 23258543


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048383 (hMKNK1/Phos:1) pT250,pT255,pT385,pS437 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9BUB5 (MKNK1) T255 P67775 (PPP2CA) unknown eFIP 20927323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S39 F39 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K332 E332 Biomuta DOID:363 / uterine cancer [ tcga ]
K338 N338 Biomuta DOID:363 / uterine cancer [ tcga ]
S413 Y413 Biomuta DOID:3571 / liver cancer [ icgc ]
S437 F437 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S460 R460 Biomuta DOID:3571 / liver cancer [ icgc ]