iPTMnet Report for Q99835 (SMO)
Protein Information
UniProt AC / UniProt ID | Q99835 / SMO_HUMAN |
Protein Name | Protein smoothened precursor |
Gene Name | Name: SMO Synonyms:SMOH; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q99835 |
PRO Name | smoothened homolog (human) |
Definition | A smoothened that is encoded in the genome of human. |
Short Label | hSMO |
Category | organism-gene |
Q99835 (SMO) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S32 | Phosphorylation | score1 | PhosphoSitePlus | |||
N35 | N-Glycosylation | score1 | GlyGen | 29671580 | ||
S43 | Phosphorylation | score1 | PhosphoSitePlus | |||
S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
T55 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
N188 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
T500 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
S588 | Phosphorylation | score1 | PRO | |||
S590 | Phosphorylation | score1 | PRO | |||
T593 | Phosphorylation | score1 | PRO | |||
S595 | Phosphorylation | score1 | PRO | |||
S611 | Phosphorylation | score1 | PRO | |||
S615 | Phosphorylation | score1 | PRO | |||
S616 | Phosphorylation | score1 | PRO | |||
K674 | Acetylation | score1 | PhosphoSitePlus | |||
S771 | Phosphorylation | score1 | PhosphoSitePlus | |||
S785 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049298 (hSMO/SigPep-/Phos:1) | pS588,pS590,pT593,pS595 | PRO | |||
PR:000049299 (hSMO/SigPep-/Phos:2) | pS588,pS590,pT593,pS595,pS611,pS615,pS616 | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S32 | L32 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
N35 | T35 | Biomuta | DOID:10283 / prostate cancer [ icgc ] | |
S590 | T590 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
S595 | F595 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S615 | F615 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S771 | F771 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S785 | L785 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |