Protein Information

Cytoscape View

UniProt AC / UniProt ID Q99835 / SMO_HUMAN
Protein Name Smoothened homolog precursor
Gene Name Name: SMO
Organism Homo sapiens (Human)

PRO ID PR:Q99835
DAG View
PRO Name smoothened homolog (human)
Definition A smoothened that is encoded in the genome of human.
Short Label hSMO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q99835 (SMO) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PRO
S590 Phosphorylation PRO
T593 Phosphorylation PRO
S595 Phosphorylation PRO
S611 Phosphorylation PRO
S615 Phosphorylation PRO
S616 Phosphorylation PRO
K674 Acetylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049298 (hSMO/SigPep-/Phos:1) pS588,pS590,pT593,pS595 PRO
PR:000049299 (hSMO/SigPep-/Phos:2) pS588,pS590,pT593,pS595,pS611,pS615,pS616 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 L32 Biomuta DOID:10283 / prostate cancer [ icgc ]
S595 F595 Biomuta DOID:1324 / lung cancer [ tcga ]
S771 F771 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S785 L785 Biomuta DOID:11934 / head and neck cancer [ tcga ]