iPTMnet Report for Q99835 (SMO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99835 / SMO_HUMAN
Protein Name Protein smoothened precursor
Gene Name Name: SMO
Synonyms:SMOH;
Organism Homo sapiens (Human)

PRO ID PR:Q99835
DAG View
PRO Name smoothened homolog (human)
Definition A smoothened that is encoded in the genome of human.
Short Label hSMO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99835 (SMO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
N35 N-Glycosylation GlyGen 29671580
S43 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T55 O-Glycosylation GlyGen 30459171
N188 N-Glycosylation GlyGen 24190977
T500 O-Glycosylation GlyGen 30459171
S588 Phosphorylation PRO
S590 Phosphorylation PRO
T593 Phosphorylation PRO
S595 Phosphorylation PRO
S611 Phosphorylation PRO
S615 Phosphorylation PRO
S616 Phosphorylation PRO
K674 Acetylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N35 N-Glycosylation PRO 29671580


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049298 (hSMO/SigPep-/Phos:1) pS588,pS590,pT593,pS595 PRO
PR:000049299 (hSMO/SigPep-/Phos:2) pS588,pS590,pT593,pS595,pS611,pS615,pS616 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 L32 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
N35 T35 Biomuta DOID:10283 / prostate cancer [ icgc ]
S590 T590 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S595 F595 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S615 F615 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S771 F771 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S785 L785 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]