iPTMnet Report for Q99714 (HSD17B10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99714 / HCD2_HUMAN
Protein Name 3-hydroxyacyl-CoA dehydrogenase type-2
Gene Name Name: HSD17B10
Synonyms:ERAB,HADH2,MRPP2,SCHAD,SDR5C1,XH98G2;
Organism Homo sapiens (Human)

PRO ID PR:Q99714
DAG View
PRO Name 3-hydroxyacyl-CoA dehydrogenase type-2 (human)
Definition A 3-hydroxyacyl-CoA dehydrogenase type-2 that is encoded in the genome of human.
Short Label hHSD17B10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99714 (HSD17B10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
C214 S-Nitrosylation dbSNO 19483679
S219 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...27655845, 34725712, 35132862, 35083852, 29485866, 32119511, 28510447, 34229054
S219 Phosphorylation PhosphoSitePlus
R258 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T153 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T153 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 L20 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K99 N99 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R258 S258 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R258 P258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R258 C258 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
R258 L258 Biomuta DOID:4159 / skin cancer [ cosmic ]