iPTMnet Report for Q99714 (HSD17B10)
Protein Information
UniProt AC / UniProt ID | Q99714 / HCD2_HUMAN |
Protein Name | 3-hydroxyacyl-CoA dehydrogenase type-2 |
Gene Name | Name: HSD17B10 Synonyms:ERAB,HADH2,MRPP2,SCHAD,SDR5C1,XH98G2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q99714 |
PRO Name | 3-hydroxyacyl-CoA dehydrogenase type-2 (human) |
Definition | A 3-hydroxyacyl-CoA dehydrogenase type-2 that is encoded in the genome of human. |
Short Label | hHSD17B10 |
Category | organism-gene |
Q99714 (HSD17B10) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 25944712 | ||
K9 | Acetylation | score1 | PhosphoSitePlus | |||
K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
S36 | Phosphorylation | score1 | PhosphoSitePlus | |||
S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
K52 | Acetylation | score1 | PhosphoSitePlus | |||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
K53 | Acetylation | score1 | PhosphoSitePlus | |||
K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
K69 | Acetylation | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
K79 | Acetylation | score1 | PhosphoSitePlus | |||
K79 | Ubiquitination | score1 | PhosphoSitePlus | |||
K99 | Acetylation | score1 | PhosphoSitePlus | |||
K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
K105 | Acetylation | score1 | PhosphoSitePlus | |||
K105 | Ubiquitination | score1 | PhosphoSitePlus | |||
T153 | Phosphorylation | score1 | PhosphoSitePlus | |||
T179 | Phosphorylation | score1 | PhosphoSitePlus | |||
T203 | Phosphorylation | score1 | PhosphoSitePlus | |||
T207 | Phosphorylation | score1 | PhosphoSitePlus | |||
S208 | Phosphorylation | score1 | PhosphoSitePlus | |||
C214 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
S219 | O-Glycosylation | score1 | GlyGen | 23301498, 16408927, 30444036, ... | ||
S219 | Phosphorylation | score1 | PhosphoSitePlus | |||
R258 | Methylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S20 | L20 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K99 | N99 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
R258 | S258 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
R258 | P258 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R258 | C258 | Biomuta | DOID:1612 / breast cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ] | |
R258 | L258 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |