iPTMnet Report Q99638 RAD9A

Protein Information

UniProt AC / UniProt ID	Q99638 / RAD9A_HUMAN
Protein Name	Cell cycle checkpoint control protein RAD9A
Gene Name	Name: RAD9A
Organism	Homo sapiens (Human)

PRO ID	PR:Q99638 DAG View
PRO Name	cell cycle checkpoint control protein RAD9A (human)
Definition	A cell cycle checkpoint control protein RAD9A that is encoded in the genome of human.
Short Label	hRAD9A
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q99638 (RAD9A) as Substrate

Q99638

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K2 K15 Y28 K96 T167 S254 S266 T268 S270 S272 S277 T292 T313 S324 S326 S328 S336 S341 S350 T351 T355 S363 S375 S380 S387	PTM Type Select all Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
K2	Methylation		score1	PhosphoSitePlus
K15	Ubiquitination		score1	PhosphoSitePlus
Y28	Phosphorylation	P00519 (ABL1) , A0A173G4P4 (Abl fusion)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	11971963, 18769057
K96	Ubiquitination		score1	PhosphoSitePlus
T167	Phosphorylation		score1	PhosphoSitePlus
S254	Phosphorylation		score1	PhosphoSitePlus
S266	Phosphorylation		score0	HPRD	20068231
T268	Phosphorylation		score1	PhosphoSitePlus
S270	Phosphorylation		score2	HPRD phospho.ELM	18669648, 20068231
S272	Phosphorylation	Q13315 (ATM)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	26658951, 11278446, 20305300, ...12709442, 12734188, 18669648, 11551919, 17511890, 22453082
S277	Phosphorylation	P06493 (CDK1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	19651622, 12734188, 12709442, ...17322306, 18669648, 29254517, 24098381, 19690332, 20068231
T292	Phosphorylation	P06493 (CDK1)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor	11551919, 12734188, 29254517
T313	Phosphorylation		score0	RLIMS-P	29254517
S324	Phosphorylation		score1	PhosphoSitePlus
S326	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	29254517
S328	Phosphorylation	P06493 (CDK1) , Q9UKI8 (TLK1) , P24941 (CDK2)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	23186163, 12734188, 23946870, ...12709442, 26860083, 19651622, 24376897, 23028682, 29254517, 18940270
S336	Phosphorylation	P06493 (CDK1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	29254517, 12734188, 12709442
S341	Phosphorylation	P68400 (CSNK2A1)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P UniProt	20545769, 12709442, 25091155, ...22925454
S350	Phosphorylation		score1	PhosphoSitePlus
T351	Phosphorylation		score1	PhosphoSitePlus
T355	Phosphorylation	Q9UKI8 (TLK1) , P06493 (CDK1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	24376897, 12709442, 12734188, ...26860083
S363	Phosphorylation		score1	PhosphoSitePlus
S375	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 17081983, 12709442, ...19651622, 18669648, 19690332, 20068231
S380	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus UniProt	12709442, 20068231, 17081983
S387	Phosphorylation	P68400 (CSNK2A1)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19413330, 21406692, 23186163, ...17081983, 20858457, 20545769, 30295604, 12709442, 12734188, 19651622, 18669648, 25091155, 26658951, 20724438, 19690332, 20068231, 22925454

PTM-dependent PPI

Search:

PTM type Select all Phosphorylation	Substrate Select all Q99638 (RAD9A)	Site Select all By amino acid All Serine All Threonine By position T292 S328 S341 S387	Interactant Select all P10415 (BCL2) P53350 (PLK1) Q07817 (BCL2L1) Q92547 (TOPBP1)	Association type Select all unknown	Source Select all eFIP	PMID
Phosphorylation	Q99638 (RAD9A)	S341	Q92547 (TOPBP1)	unknown	eFIP	26658951
Phosphorylation	Q99638 (RAD9A)	S328	P10415 (BCL2)	unknown	eFIP	23028682
Phosphorylation	Q99638 (RAD9A)	S387	Q92547 (TOPBP1)	unknown	eFIP	30295604
Phosphorylation	Q99638 (RAD9A)	T292	P53350 (PLK1)	unknown	eFIP	29254517
Phosphorylation	Q99638 (RAD9A)	S341	Q92547 (TOPBP1)	unknown	eFIP	25091155
Phosphorylation	Q99638 (RAD9A)	S328	Q07817 (BCL2L1)	unknown	eFIP	23028682

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position K15 S266 S272 S277	Variant Select all C272 E15 L266 T277	Source Select all Biomuta	Disease [Sample source] Select all DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ]
K15	E15	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S266	L266	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S272	C272	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S277	T277	Biomuta	DOID:1612 / breast cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q99638 (RAD9A)

Protein Information

Interactive Sequence View

Q99638 (RAD9A) as Substrate

PTM-dependent PPI

PTM sites affected in variants