iPTMnet Report for Q99570 (PIK3R4)
Protein Information
UniProt AC / UniProt ID | Q99570 / PI3R4_HUMAN |
Protein Name | Phosphoinositide 3-kinase regulatory subunit 4 |
Gene Name | Name: PIK3R4 Synonyms:VPS15; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q99570 |
PRO Name | phosphoinositide 3-kinase regulatory subunit 4 (human) |
Definition | A phosphoinositide 3-kinase regulatory subunit 4 that is encoded in the genome of human. |
Short Label | hPIK3R4 |
Category | organism-gene |
Q99570 (PIK3R4) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
G2 | Myristoylation | score3 | UniProt | 8999962, 25255805 | ||
T61 | Phosphorylation | score1 | PhosphoSitePlus | |||
K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
K75 | Ubiquitination | score1 | PhosphoSitePlus | |||
K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
T116 | Phosphorylation | score1 | PhosphoSitePlus | |||
S169 | Phosphorylation | score1 | PhosphoSitePlus | |||
T220 | Phosphorylation | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
S338 | Phosphorylation | score1 | PhosphoSitePlus | |||
K348 | Ubiquitination | score1 | PhosphoSitePlus | |||
C385 | Methylation | score1 | IEDB | 31844290 | ||
K443 | Ubiquitination | score1 | PhosphoSitePlus | |||
K449 | Ubiquitination | score1 | PhosphoSitePlus | |||
K553 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y673 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19664994 | ||
T680 | Phosphorylation | score1 | PhosphoSitePlus | |||
C693 | Methylation | score1 | IEDB | 31844290 | ||
K713 | Ubiquitination | score1 | PhosphoSitePlus | |||
K736 | Ubiquitination | score1 | PhosphoSitePlus | |||
S740 | Phosphorylation | score1 | PhosphoSitePlus | |||
K772 | Ubiquitination | score1 | PhosphoSitePlus | |||
K773 | Ubiquitination | score1 | PhosphoSitePlus | |||
T780 | Phosphorylation | score1 | PhosphoSitePlus | |||
K786 | Ubiquitination | score1 | PhosphoSitePlus | |||
K791 | Ubiquitination | score1 | PhosphoSitePlus | |||
K801 | Ubiquitination | score1 | PhosphoSitePlus | |||
S808 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
S813 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 23186163, 20068231 | ||
S814 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
K816 | Ubiquitination | score1 | PhosphoSitePlus | |||
K835 | Ubiquitination | score1 | PhosphoSitePlus | |||
K850 | Ubiquitination | score1 | PhosphoSitePlus | |||
S853 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 19369195 | ||
S861 | Phosphorylation | score1 | PhosphoSitePlus | |||
S865 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 19369195, 18691976 | ||
K888 | Ubiquitination | score1 | PhosphoSitePlus | |||
S892 | Phosphorylation | score1 | PhosphoSitePlus | |||
S894 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
K918 | Ubiquitination | score1 | PhosphoSitePlus | |||
S925 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S926 | Phosphorylation | score0 | HPRD | 18669648 | ||
T927 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
S931 | Phosphorylation | score0 | HPRD | 20068231 | ||
K941 | Ubiquitination | score1 | PhosphoSitePlus | |||
T942 | Phosphorylation | score1 | PhosphoSitePlus | |||
K951 | Acetylation | score1 | PhosphoSitePlus | |||
K951 | Ubiquitination | score1 | PhosphoSitePlus | |||
K962 | Ubiquitination | score1 | PhosphoSitePlus | |||
K973 | Ubiquitination | score1 | PhosphoSitePlus | |||
K993 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1018 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y1038 | Phosphorylation | score0 | HPRD | 20068231 | ||
S1074 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1079 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1081 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y1272 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1282 | Phosphorylation | score0 | HPRD | 18669648 | ||
T1283 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
S1287 | Phosphorylation | score0 | HPRD | 18669648 | ||
S1289 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
Y1290 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648 | ||
Y1291 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
K1293 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1307 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1309 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1316 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K89 | R89 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T116 | A116 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
C385 | F385 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
C385 | Y385 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
K443 | N443 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K801 | E801 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S813 | N813 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S814 | T814 | Biomuta | DOID:3277 / thymus cancer [ cosmic ] | |
S892 | F892 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] | |
K918 | N918 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
S1079 | F1079 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S1282 | I1282 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K1309 | N1309 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
K1309 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] |