Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99570 / PI3R4_HUMAN
Protein Name Phosphoinositide 3-kinase regulatory subunit 4
Gene Name Name: PIK3R4
Synonyms:VPS15;
Organism Homo sapiens (Human)

PRO ID PR:Q99570
DAG View
PRO Name phosphoinositide 3-kinase regulatory subunit 4 (human)
Definition A phosphoinositide 3-kinase regulatory subunit 4 that is encoded in the genome of human.
Short Label hPIK3R4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99570 (PIK3R4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 8999962, 25255805
T61 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
Y673 Phosphorylation HPRD   PhosphoSitePlus 19664994
T680 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
T780 Phosphorylation PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus   UniProt 19369195
S813 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
S814 Phosphorylation HPRD   PhosphoSitePlus 20068231
K816 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K850 Ubiquitination PhosphoSitePlus
S853 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
S861 Phosphorylation PhosphoSitePlus
S865 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19369195, 18691976
K888 Ubiquitination PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S894 Phosphorylation HPRD   PhosphoSitePlus 20068231
K918 Ubiquitination PhosphoSitePlus
S925 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S926 Phosphorylation HPRD 18669648
T927 Phosphorylation HPRD   PhosphoSitePlus 18669648
S931 Phosphorylation HPRD 20068231
K941 Ubiquitination PhosphoSitePlus
T942 Phosphorylation PhosphoSitePlus
K951 Acetylation PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
K973 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
Y1038 Phosphorylation HPRD 20068231
S1074 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
Y1272 Phosphorylation PhosphoSitePlus
S1282 Phosphorylation HPRD 18669648
T1283 Phosphorylation HPRD   PhosphoSitePlus 18669648
S1287 Phosphorylation HPRD 18669648
S1289 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y1290 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y1291 Phosphorylation HPRD   PhosphoSitePlus 18669648
K1293 Ubiquitination PhosphoSitePlus
K1307 Ubiquitination PhosphoSitePlus
K1309 Ubiquitination PhosphoSitePlus
T1316 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P63244 (RACK1) T50 Q99570 (PIK3R4) unknown eFIP 26549445


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K89 R89 Biomuta DOID:363 / uterine cancer [ tcga ]
T116 A116 Biomuta DOID:363 / uterine cancer [ tcga ]
K801 E801 Biomuta DOID:363 / uterine cancer [ tcga ]
S813 N813 Biomuta DOID:363 / uterine cancer [ tcga ]
K918 N918 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y1272 * Biomuta DOID:3571 / liver cancer [ icgc ]
K1309 N1309 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K1309 * Biomuta DOID:1324 / lung cancer [ tcga ]