iPTMnet Report for Q96SB4 (SRPK1)
Protein Information
| UniProt AC / UniProt ID | Q96SB4 / SRPK1_HUMAN |
| Protein Name | SRSF protein kinase 1 |
| Gene Name | Name: SRPK1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96SB4 |
| PRO Name | SRSF protein kinase 1 (human) |
| Definition | An SRSF protein kinase 1 that is encoded in the genome of human. |
| Short Label | hSRPK1 |
| Category | organism-gene |
DAG ViewQ96SB4 (SRPK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K4 | Acetylation | score1 | PhosphoSitePlus | |||
| K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K12 | Acetylation | score1 | PhosphoSitePlus | |||
| K13 | Acetylation | score1 | PhosphoSitePlus | |||
| K16 | Acetylation | score1 | PhosphoSitePlus | |||
| S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T28 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score3 | PhosphoSitePlus Signor | 22727668 | ||
| S33 | Phosphorylation | Q96SB4 (SRPK1) | score3 | PhosphoSitePlus Signor | 22727668 | |
| S37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S39 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S51 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 12565829, 18691976, 23186163, ... | ||
| S51 | Phosphorylation | P19784 (CSNK2A2) | score2 | PhosphoSitePlus | 12565829 | |
| S51 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 12565829 | |
| Y62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S113 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y117 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C162 | Methylation | score1 | IEDB | 31844290 | ||
| S222 | Phosphorylation | score3 | phospho.ELM | 12565829, 17081983 | ||
| S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S252 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K284 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S309 | Phosphorylation | score4 | PhosphoSitePlus Signor UniProt | 23186163, 22727668, 24275569 | ||
| S309 | Phosphorylation | Q96SB4 (SRPK1) | score3 | PhosphoSitePlus Signor | 22727668 | |
| S311 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
| T326 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor | 33808326, 22727668 | ||
| T326 | Phosphorylation | Q96SB4 (SRPK1) | score3 | neXtProt PhosphoSitePlus Signor | 22727668 | |
| S333 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S334 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y365 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T373 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S408 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 33808326 | ||
| S473 | Phosphorylation | score0 | RLIMS-P | 32461560 | ||
| K486 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K494 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K506 | Acetylation | score1 | PhosphoSitePlus | |||
| K506 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T514 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R515 | Methylation | score1 | PhosphoSitePlus | |||
| S555 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 12565829 | ||
| S555 | Phosphorylation | P19784 (CSNK2A2) | score2 | PhosphoSitePlus | 12565829 | |
| S555 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 12565829 | |
| K579 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K585 | Acetylation | score1 | PhosphoSitePlus | |||
| K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S587 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 22727668 | ||
| S587 | Phosphorylation | Q96SB4 (SRPK1) | score3 | neXtProt PhosphoSitePlus | 22727668 | |
| K588 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K604 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S33 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 18452278 | ||
| S37 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 18452278 | ||
| S39 | Phosphorylation | score0 | HPRD | 18669648, 18452278 | ||
| S51 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 17081983, ... | ||
| S309 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 19651622, ... | ||
| S311 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 19651622, ... | ||
| T514 | Phosphorylation | score0 | HPRD | 19651622, 20068231 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S18 | Phosphorylation | score1 | PhosphoSitePlus |
Q96SB4 (SRPK1) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S113 | I113 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S249 | Y249 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S334 | G334 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| T373 | I373 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S473 | F473 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K506 | R506 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S587 | F587 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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