Protein Information

Cytoscape View

UniProt AC / UniProt ID Q96SB4 / SRPK1_HUMAN
Protein Name SRSF protein kinase 1
Gene Name Name: SRPK1
Organism Homo sapiens (Human)

DAG View
PRO Name SRSF protein kinase 1 (human)
Definition An SRSF protein kinase 1 that is encoded in the genome of human.
Short Label hSRPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q96SB4 (SRPK1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
S33 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus   Signor 22727668
S37 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S51 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 12565829, 23186163, 17081983, ...18691976, 18669648, 19690332
Y62 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S222 Phosphorylation phospho.ELM 12565829, 17081983
S249 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S309 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus   Signor   UniProt 23186163, 22727668, 24275569
S311 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T326 Phosphorylation Q96SB4 (SRPK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 33808326, 22727668
S333 Phosphorylation PhosphoSitePlus   UniProt 23186163
S334 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S408 Phosphorylation RLIMS-P 33808326
S473 Phosphorylation RLIMS-P 32461560
K486 Ubiquitination PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
R515 Methylation PhosphoSitePlus
S555 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 12565829
K579 Ubiquitination PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S587 Phosphorylation Q96SB4 (SRPK1) neXtProt   PhosphoSitePlus 22727668
K588 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation HPRD 18691976, 18669648, 18452278
S37 Phosphorylation HPRD 19413330, 18669648, 18452278
S39 Phosphorylation HPRD 18669648, 18452278
S51 Phosphorylation HPRD 19413330, 18691976, 17081983, ...18452278, 18669648, 19415658
S309 Phosphorylation HPRD 19413330, 18691976, 19651622, ...20068231, 18767875
S311 Phosphorylation HPRD 19413330, 18691976, 19651622, ...18767875
T514 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus

Q96SB4 (SRPK1) as PTM Enzyme

Substrate Site Score Source PMID
Q07955 (SRSF1) S205 PhosphoSitePlus 18155240
Q07955 (SRSF1) S207 PhosphoSitePlus 18155240
Q07955 (SRSF1) S209 PhosphoSitePlus 18155240
Q07955 (SRSF1) S211 PhosphoSitePlus 18155240
Q07955 (SRSF1) S213 PhosphoSitePlus 18155240
Q07955 (SRSF1) S215 PhosphoSitePlus 18155240
Q07955 (SRSF1) S217 PhosphoSitePlus 18155240
Q07955 (SRSF1) S219 PhosphoSitePlus 18155240
Q07955 (SRSF1) S221 PhosphoSitePlus 18155240
Q07955 (SRSF1) S223 PhosphoSitePlus 18155240
Q07955 (SRSF1) S225 PhosphoSitePlus 18155240
Q07955 (SRSF1) S227 PhosphoSitePlus 18155240
Q96SB4 (SRPK1) S33 PhosphoSitePlus   Signor 22727668
Q96SB4 (SRPK1) S309 PhosphoSitePlus   Signor 22727668
Q96SB4 (SRPK1) T326 neXtProt   PhosphoSitePlus   Signor 22727668
Q96SB4 (SRPK1) S587 neXtProt   PhosphoSitePlus 22727668
Q9BWF3 (RBM4) S309 PhosphoSitePlus 17284590
Q9Y5S9 (RBM8A) S166 PhosphoSitePlus   Signor 16100109
Q9Y5S9 (RBM8A) S168 PhosphoSitePlus   Signor 16100109

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 I113 Biomuta DOID:363 / uterine cancer [ tcga ]
S249 Y249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T326 N326 Biomuta DOID:3571 / liver cancer [ icgc ]
T373 I373 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S473 F473 Biomuta DOID:363 / uterine cancer [ tcga ]
S587 F587 Biomuta DOID:1909 / melanoma [ icgc, tcga ]