iPTMnet Report for Q96S94 (CCNL2)
Protein Information
| UniProt AC / UniProt ID | Q96S94 / CCNL2_HUMAN |
| Protein Name | Cyclin-L2 |
| Gene Name | Name: CCNL2 ORFNames:SB138; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96S94 |
| PRO Name | cyclin-L2 (human) |
| Definition | A cyclin-L2 that is encoded in the genome of human. |
| Short Label | hCCNL2 |
| Category | organism-gene |
Q96S94 (CCNL2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 22814378, 22223895 | ||
| S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T326 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S327 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S330 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 21406692, 23186163, 24275569, ... | ||
| S330 | Phosphorylation | Q13627 (DYRK1A) | score2 | PhosphoSitePlus | 14623875 | |
| S338 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 14623875, 23186163, 20068231, ... | ||
| S338 | Phosphorylation | Q13627 (DYRK1A) | score2 | PhosphoSitePlus | 14623875 | |
| S345 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17081983 | ||
| S348 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S351 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 17081983 | ||
| K364 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K366 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S369 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | ||
| S369 | Phosphorylation | Q13627 (DYRK1A) | score2 | PhosphoSitePlus | 14623875 | |
| S386 | Phosphorylation | score2 | IEDB | 22645359 | ||
| S400 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S423 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S425 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S435 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S441 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S449 | O-Glycosylation | score1 | GlyGen | 30379171, 28411811, 29351928 | ||
| S461 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K482 | Acetylation | score1 | PhosphoSitePlus | |||
| Y483 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S498 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S500 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S516 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T101 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T326 | Phosphorylation | score0 | HPRD | 19664995 | ||
| S330 | Phosphorylation | score0 | HPRD | 17322306, 18767875, 19651622, ... | ||
| S338 | Phosphorylation | score2 | HPRD | 14623875, 20068231 | ||
| S338 | Phosphorylation | Q13627 (DYRK1A) | score2 | HPRD | 14623875, 20068231 | |
| S345 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S351 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S369 | Phosphorylation | score2 | HPRD | 19413330, 19664994, 19664995, ... | ||
| S369 | Phosphorylation | Q13627 (DYRK1A) | score2 | HPRD | 19413330, 19664994, 19664995, ... | |
| S406 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S408 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S410 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T411 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S419 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S25 | C25 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K288 | R288 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K288 | T288 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K288 | N288 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| S327 | L327 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S338 | F338 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S386 | G386 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S441 | F441 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S461 | F461 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S500 | L500 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View