Protein Information

Cytoscape View

UniProt AC / UniProt ID Q96S94 / CCNL2_HUMAN
Protein Name Cyclin-L2
Gene Name Name: CCNL2
Organism Homo sapiens (Human)

DAG View
PRO Name cyclin-L2 (human)
Definition A cyclin-L2 that is encoded in the genome of human.
Short Label hCCNL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q96S94 (CCNL2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S25 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S330 Phosphorylation Q13627 (DYRK1A) PhosphoSitePlus   UniProt 21406692, 23186163, 24275569, ...14623875, 19690332, 20068231
S338 Phosphorylation Q13627 (DYRK1A) PhosphoSitePlus   UniProt 14623875, 23186163, 20068231, ...24275569
S345 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S348 Phosphorylation PhosphoSitePlus   UniProt 21406692
S351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
K364 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S369 Phosphorylation Q13627 (DYRK1A) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 14623875
S400 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S449 O-Glycosylation GlyGen 28411811, 29351928
S461 Phosphorylation PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T101 Phosphorylation HPRD 20068231
T326 Phosphorylation HPRD 19664995
S330 Phosphorylation HPRD 17322306, 18767875, 19651622, ...19664995, 20068231
S338 Phosphorylation Q13627 (DYRK1A) HPRD 14623875, 20068231
S345 Phosphorylation HPRD 17081983
S351 Phosphorylation HPRD 17081983
S369 Phosphorylation Q13627 (DYRK1A) HPRD 19413330, 19664994, 19664995, ...18452278, 19651622, 18669648, 14623875
S406 Phosphorylation HPRD 20068231
S408 Phosphorylation HPRD 20068231
S410 Phosphorylation HPRD 20068231
T411 Phosphorylation HPRD 20068231
S419 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T101 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K288 R288 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K288 T288 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K288 N288 Biomuta DOID:3070 / malignant glioma [ tcga ]
S327 L327 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S338 F338 Biomuta DOID:363 / uterine cancer [ tcga ]
S441 F441 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y483 * Biomuta DOID:3571 / liver cancer [ icgc ]
S500 L500 Biomuta DOID:1909 / melanoma [ cosmic ]