iPTMnet Report for Q96S94 (CCNL2)
Protein Information
UniProt AC / UniProt ID | Q96S94 / CCNL2_HUMAN |
Protein Name | Cyclin-L2 |
Gene Name | Name: CCNL2 ORFNames:SB138; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96S94 |
PRO Name | cyclin-L2 (human) |
Definition | A cyclin-L2 that is encoded in the genome of human. |
Short Label | hCCNL2 |
Category | organism-gene |
Q96S94 (CCNL2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 22814378, 22223895 | ||
S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
T101 | Phosphorylation | score1 | PhosphoSitePlus | |||
K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
T326 | Phosphorylation | score1 | PhosphoSitePlus | |||
S327 | Phosphorylation | score1 | PhosphoSitePlus | |||
S330 | Phosphorylation | Q13627 (DYRK1A) | score4 | PhosphoSitePlus UniProt | 21406692, 23186163, 24275569, ... | |
S338 | Phosphorylation | Q13627 (DYRK1A) | score4 | PhosphoSitePlus UniProt | 14623875, 23186163, 20068231, ... | |
S345 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17081983 | ||
S348 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S351 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 17081983 | ||
K364 | Ubiquitination | score1 | PhosphoSitePlus | |||
K366 | Ubiquitination | score1 | PhosphoSitePlus | |||
S369 | Phosphorylation | Q13627 (DYRK1A) | score4 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | |
S386 | Phosphorylation | score2 | IEDB | 22645359 | ||
S400 | Phosphorylation | score1 | PhosphoSitePlus | |||
S423 | Phosphorylation | score1 | PhosphoSitePlus | |||
S425 | Phosphorylation | score1 | PhosphoSitePlus | |||
S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
S435 | Phosphorylation | score1 | PhosphoSitePlus | |||
S441 | Phosphorylation | score1 | PhosphoSitePlus | |||
S449 | O-Glycosylation | score1 | GlyGen | 30379171, 28411811, 29351928 | ||
S461 | Phosphorylation | score1 | PhosphoSitePlus | |||
K482 | Acetylation | score1 | PhosphoSitePlus | |||
Y483 | Phosphorylation | score1 | PhosphoSitePlus | |||
S498 | Phosphorylation | score1 | PhosphoSitePlus | |||
S500 | Phosphorylation | score1 | PhosphoSitePlus | |||
S516 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T101 | Phosphorylation | score0 | HPRD | 20068231 | ||
T326 | Phosphorylation | score0 | HPRD | 19664995 | ||
S330 | Phosphorylation | score0 | HPRD | 17322306, 18767875, 19651622, ... | ||
S338 | Phosphorylation | Q13627 (DYRK1A) | score2 | HPRD | 14623875, 20068231 | |
S345 | Phosphorylation | score0 | HPRD | 17081983 | ||
S351 | Phosphorylation | score0 | HPRD | 17081983 | ||
S369 | Phosphorylation | Q13627 (DYRK1A) | score2 | HPRD | 19413330, 19664994, 19664995, ... | |
S406 | Phosphorylation | score0 | HPRD | 20068231 | ||
S408 | Phosphorylation | score0 | HPRD | 20068231 | ||
S410 | Phosphorylation | score0 | HPRD | 20068231 | ||
T411 | Phosphorylation | score0 | HPRD | 20068231 | ||
S419 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S25 | C25 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K288 | R288 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K288 | T288 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K288 | N288 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
S327 | L327 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
S338 | F338 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S386 | G386 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S441 | F441 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S461 | F461 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S500 | L500 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |