Protein Information

Cytoscape View

UniProt AC / UniProt ID Q96S52 / PIGS_HUMAN
Protein Name GPI transamidase component PIG-S
Gene Name Name: PIGS
Organism Homo sapiens (Human)

DAG View
PRO Name GPI transamidase component PIG-S (human)
Definition A GPI transamidase component PIG-S that is encoded in the genome of human.
Short Label hPIGS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q96S52 (PIGS) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K81 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
N370 N-Glycosylation GlyGen 29741879, 24190977
S372 O-Glycosylation GlyGen 28510447, 30059200
T437 Phosphorylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 R95 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T440 N440 Biomuta DOID:3571 / liver cancer [ icgc ]
T440 S440 Biomuta DOID:1319 / brain cancer [ icgc ]