iPTMnet Report for Q96RI1 (NR1H4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RI1 / NR1H4_HUMAN
Protein Name Bile acid receptor
Gene Name Name: NR1H4
Synonyms:BAR,FXR,HRR1,RIP14;
Organism Homo sapiens (Human)

PRO ID PR:Q96RI1
DAG View
PRO Name bile acid receptor (human)
Definition A bile acid receptor that is encoded in the genome of human.
Short Label hNR1H4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RI1 (NR1H4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y77 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S145 Phosphorylation P17252 (PRKCA) Signor   UniProt 18755856
S164 Phosphorylation P17252 (PRKCA) Signor   UniProt 18755856
K167 Acetylation PhosphoSitePlus
K220 Methylation UniProt 22345554
K227 Acetylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
T456 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   Signor   UniProt 18668687
S467 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K157 Acetylation PR:000007102 (EP300) PRO 19883617
K217 Acetylation PR:000007102 (EP300) PRO 19883617
Site PTM Type PTM Enzyme Score Source PMID
K122 Sumoylation PhosphoSitePlus
S135 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18755856
S154 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18755856
K275 Sumoylation PhosphoSitePlus
T442 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18668687


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028577 (hNR1H4/iso:1/Ac:1) acK157,acK217 PR:000007102 (EP300) PRO 19883617


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y91 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y91 C91 Biomuta DOID:263 / kidney cancer [ cosmic ]
S135 P135 Biomuta DOID:1324 / lung cancer [ cosmic ]
S145 P145 Biomuta DOID:1324 / lung cancer [ cosmic ]
S154 R154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S164 R164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K227 N227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S372 T372 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]