iPTMnet Report for Q96RI1 (NR1H4)
Protein Information
| UniProt AC / UniProt ID | Q96RI1 / NR1H4_HUMAN |
| Protein Name | Bile acid receptor |
| Gene Name | Name: NR1H4 Synonyms:BAR,FXR,HRR1,RIP14; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96RI1 |
| PRO Name | bile acid receptor (human) |
| Definition | A bile acid receptor that is encoded in the genome of human. |
| Short Label | hNR1H4 |
| Category | organism-gene |
DAG ViewQ96RI1 (NR1H4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y77 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y91 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y107 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S145 | Phosphorylation | score3 | Signor UniProt | 18755856 | ||
| S145 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 18755856 | |
| S164 | Phosphorylation | score3 | Signor UniProt | 18755856 | ||
| S164 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 18755856 | |
| K167 | Acetylation | score1 | PhosphoSitePlus | |||
| K220 | Methylation | score2 | UniProt | 22345554 | ||
| K227 | Acetylation | score1 | PhosphoSitePlus | |||
| S369 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T456 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 18668687 | ||
| T456 | Phosphorylation | Q05513 (PRKCZ) | score1 | Signor | 18668687 | |
| S467 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K157 | Acetylation | score2 | PRO | 19883617 | ||
| K157 | Acetylation | PR:000007102 (EP300) | score2 | PRO | 19883617 | |
| K217 | Acetylation | score2 | PRO | 19883617 | ||
| K217 | Acetylation | PR:000007102 (EP300) | score2 | PRO | 19883617 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K122 | Sumoylation | score1 | PhosphoSitePlus | |||
| S135 | Phosphorylation | score2 | PhosphoSitePlus | 18755856 | ||
| S135 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 18755856 | |
| S154 | Phosphorylation | score2 | PhosphoSitePlus | 18755856 | ||
| S154 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 18755856 | |
| K275 | Sumoylation | score1 | PhosphoSitePlus | |||
| T442 | Phosphorylation | score2 | PhosphoSitePlus | 18668687 | ||
| T442 | Phosphorylation | Q05513 (PRKCZ) | score2 | PhosphoSitePlus | 18668687 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000028577 (hNR1H4/iso:1/Ac:1) | acK157,acK217 | PR:000007102 (EP300) | PRO | 19883617 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y91 | * | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| Y91 | C91 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S135 | P135 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S145 | P145 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S154 | R154 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S164 | R164 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K227 | N227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S372 | T372 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
