iPTMnet Report Q96QV6 H2AC1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96QV6 / H2A1A_HUMAN
Protein Name	Histone H2A type 1-A
Gene Name	Name: H2AC1 Synonyms:H2AFR,HIST1H2AA;
Organism	Homo sapiens (Human)

PRO ID	PR:Q96QV6 DAG View
PRO Name	histone H2A type 1-A (human)
Definition	A histone H2A type 1-A that is encoded in the genome of human.
Short Label	hH2AC1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96QV6 (H2AC1) as Substrate

Q96QV6

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
		Acetylation		score1	PRO
	S2	Acetylation		score1	UniProt	15823041
	S2	Phosphorylation		score2	PRO UniProt	15010469
	K6	Acetylation		score1	PRO	17709392
	K10	Acetylation		score1	PRO	18552846, 12937907
	K14	Ubiquitination		score1	UniProt	22713238, 22980979
	K16	Ubiquitination		score1	UniProt	22713238, 22980979
	S19	Phosphorylation		score1	PhosphoSitePlus
	Q105	Methylation		score1	UniProt	24352239
	K119	Acetylation		score1	PhosphoSitePlus
	K119	Ubiquitination		score1	PhosphoSitePlus
	K120	Ubiquitination		score2	PRO UniProt	18400894, 16359901, 15386022, ...25470042, 16702407
	T121	Phosphorylation		score1	UniProt	24140421, 15078818

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000044901 (hHIST1H2AA/InitMet-/Ac:1)	acK6		PRO	17709392
	PR:000044902 (hHIST1H2AA/InitMet-/Ubiq:1)	ubK120		PRO	15386022, 18400894
	PR:000044903 (hHIST1H2AA/InitMet-/Phos:1)	pS2		PRO	15010469
	PR:000044905 (hHIST1H2AA/InitMet-/Ac:2)	acK10		PRO	12937907, 18552846
	PR:000047712 (hHIST1H2AA/InitMet-/N6AcLys+)	ac		PRO

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S2	F2	Biomuta		DOID:4159 / skin cancer [ cosmic ]
Q105	H105	Biomuta		DOID:1324 / lung cancer [ cosmic ]
K119	*	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]