Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96QV6 / H2A1A_HUMAN
Protein Name Histone H2A type 1-A
Gene Name Name: HIST1H2AA
Synonyms:H2AFR;
Organism Homo sapiens (Human)

PRO ID PR:Q96QV6
DAG View
PRO Name histone H2A type 1-A (human)
Definition A histone H2A type 1-A that is encoded in the genome of human.
Short Label hHIST1H2AA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96QV6 (HIST1H2AA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041
S2 Phosphorylation PRO   UniProt 15010469
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S19 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO   UniProt 18400894, 16359901, 15386022, ...25470042, 16702407
T121 Phosphorylation UniProt 24140421, 15078818


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044901 (hHIST1H2AA/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044902 (hHIST1H2AA/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044903 (hHIST1H2AA/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044905 (hHIST1H2AA/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000047704 (hHIST1H2AA/InitMet-/Ac:3) acK6 PRO
PR:000047712 (hHIST1H2AA/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Q105 H105 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]