iPTMnet Report for Q96PH1 (NOX5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PH1 / NOX5_HUMAN
Protein Name NADPH oxidase 5
Gene Name Name: NOX5
Organism Homo sapiens (Human)

PRO ID PR:Q96PH1
DAG View
PRO Name NADPH oxidase 5 (human)
Definition An NADPH oxidase 5 that is encoded in the genome of human.
Short Label hNOX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PH1 (NOX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S456 Phosphorylation PhosphoSitePlus
D475 Phosphorylation UniProt 21642394
Y476 Phosphorylation PhosphoSitePlus   RLIMS-P 32792487
Y478 Phosphorylation PhosphoSitePlus   RLIMS-P 32792487
H490 Phosphorylation UniProt 22387196, 24505490
I494 Phosphorylation UniProt 22387196, 24505490, 21642394
P498 Phosphorylation UniProt 22387196, 24505490, 21642394
D502 Phosphorylation UniProt 21642394
S536 Phosphorylation P17252 (PRKCA) Signor 24505490
T540 Phosphorylation P17252 (PRKCA) Signor 24505490
S544 Phosphorylation P28482 (MAPK1) , P17252 (PRKCA) Signor 24505490, 21297032
D659 Phosphorylation UniProt 21642394
Site PTM Type PTM Enzyme Score Source PMID
S475 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 21642394
S490 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24505490
T494 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) PhosphoSitePlus 24505490, 17164239
S498 Phosphorylation P17252 (PRKCA) , P28482 (MAPK1) , P05771 (PRKCB) PhosphoSitePlus 24505490, 21297032, 17164239
S502 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14289 (PTK2B) Y402 Q96PH1 (NOX5) unknown eFIP 32792487
Phosphorylation Q96PH1 (NOX5) Y476 Q14289 (PTK2B) increased_association eFIP 32792487


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y478 N478 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
D659 H659 Biomuta DOID:1612 / breast cancer [ cosmic ]