iPTMnet Report Q96PH1 NOX5

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96PH1 / NOX5_HUMAN
Protein Name	NADPH oxidase 5
Gene Name	Name: NOX5
Organism	Homo sapiens (Human)

PRO ID	PR:Q96PH1 DAG View
PRO Name	NADPH oxidase 5 (human)
Definition	An NADPH oxidase 5 that is encoded in the genome of human.
Short Label	hNOX5
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96PH1 (NOX5) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S456	Phosphorylation		score1	PhosphoSitePlus
	D475	Phosphorylation		score2	UniProt	21642394
	Y476	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32792487
	Y478	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32792487
	H490	Phosphorylation		score3	UniProt	22387196, 24505490
	I494	Phosphorylation		score3	UniProt	22387196, 24505490, 21642394
	P498	Phosphorylation		score3	UniProt	22387196, 24505490, 21642394
	D502	Phosphorylation		score2	UniProt	21642394
	S536	Phosphorylation		score1	Signor	24505490
	S536	Phosphorylation	P17252 (PRKCA)	score1	Signor	24505490
	T540	Phosphorylation		score1	Signor	24505490
	T540	Phosphorylation	P17252 (PRKCA)	score1	Signor	24505490
	S544	Phosphorylation		score2	Signor	24505490, 21297032
	S544	Phosphorylation	P17252 (PRKCA)	score1	Signor	24505490
	S544	Phosphorylation	P28482 (MAPK1)	score1	Signor	21297032
	D659	Phosphorylation		score2	UniProt	21642394

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S475	Phosphorylation		score2	PhosphoSitePlus	21642394
	S475	Phosphorylation	Q9UQM7 (CAMK2A)	score2	PhosphoSitePlus	21642394
	S490	Phosphorylation		score2	PhosphoSitePlus	24505490
	S490	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	24505490
	T494	Phosphorylation		score3	PhosphoSitePlus	24505490, 17164239
	T494	Phosphorylation	P05771 (PRKCB)	score2	PhosphoSitePlus	17164239
	T494	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	24505490
	S498	Phosphorylation		score3	PhosphoSitePlus	24505490, 21297032, 17164239
	S498	Phosphorylation	P05771 (PRKCB)	score2	PhosphoSitePlus	17164239
	S498	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	24505490
	S498	Phosphorylation	P28482 (MAPK1)	score2	PhosphoSitePlus	21297032
	S502	Phosphorylation		score1	PhosphoSitePlus
	S659	Phosphorylation		score1	PhosphoSitePlus
	S675	Phosphorylation		score1	PhosphoSitePlus

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q14289 (PTK2B)	Y402	Q96PH1 (NOX5)	unknown	eFIP	32792487
	Phosphorylation	Q96PH1 (NOX5)	Y476	Q14289 (PTK2B)	increased_association	eFIP	32792487

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y478	N478	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
D659	H659	Biomuta		DOID:1612 / breast cancer [ cosmic ]