iPTMnet Report Q96LA8 PRMT6

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96LA8 / ANM6_HUMAN
Protein Name	Protein arginine N-methyltransferase 6
Gene Name	Name: PRMT6 Synonyms:HRMT1L6;
Organism	Homo sapiens (Human)

PRO ID	PR:Q96LA8 DAG View
PRO Name	protein arginine N-methyltransferase 6 (human)
Definition	A protein arginine N-methyltransferase 6 that is encoded in the genome of human.
Short Label	hPRMT6
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96LA8 (PRMT6) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S11	Phosphorylation		score1	PhosphoSitePlus
	T21	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163
	R29	Methylation	Q96LA8 (PRMT6)	score3	PhosphoSitePlus UniProt	23866860
	R35	Methylation	Q96LA8 (PRMT6)	score3	PhosphoSitePlus UniProt	23866860
	R37	Methylation	Q96LA8 (PRMT6)	score3	PhosphoSitePlus UniProt	23866860
	R38	Methylation		score1	PhosphoSitePlus
	K40	Methylation		score1	PhosphoSitePlus
	R43	Methylation		score1	PhosphoSitePlus
	Y215	Phosphorylation		score1	PhosphoSitePlus
	C221	S-Nitrosylation		score0	dbSNO	24105792
	T227	Phosphorylation		score1	PhosphoSitePlus
	C229	S-Nitrosylation		score0	dbSNO	24105792
	Y324	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T21	Phosphorylation		score0	HPRD	19651622, 18691976

Q96LA8 (PRMT6) as PTM Enzyme

Protein as Methylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q96LA8 (PRMT6)	R29	score2	UniProt	23866860
	Q96LA8 (PRMT6)	R35	score2	UniProt	23866860
	Q96LA8 (PRMT6)	R37	score2	UniProt	23866860

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R38	K38	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
R38	M38	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
Y215	C215	Biomuta		DOID:1319 / brain cancer [ cosmic ]
C221	Y221	Biomuta		DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T227	M227	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]