iPTMnet Report for Q96LA8 (PRMT6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96LA8 / ANM6_HUMAN
Protein Name Protein arginine N-methyltransferase 6
Gene Name Name: PRMT6
Synonyms:HRMT1L6;
Organism Homo sapiens (Human)

PRO ID PR:Q96LA8
DAG View
PRO Name protein arginine N-methyltransferase 6 (human)
Definition A protein arginine N-methyltransferase 6 that is encoded in the genome of human.
Short Label hPRMT6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96LA8 (PRMT6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
R29 Methylation PhosphoSitePlus   UniProt 23866860
R29 Methylation Q96LA8 (PRMT6) UniProt 23866860
R35 Methylation PhosphoSitePlus   UniProt 23866860
R35 Methylation Q96LA8 (PRMT6) UniProt 23866860
R37 Methylation PhosphoSitePlus   UniProt 23866860
R37 Methylation Q96LA8 (PRMT6) UniProt 23866860
R38 Methylation PhosphoSitePlus
K40 Methylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
C221 S-Nitrosylation dbSNO 24105792
T227 Phosphorylation PhosphoSitePlus
C229 S-Nitrosylation dbSNO 24105792
Y324 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation HPRD 19651622, 18691976


Q96LA8 (PRMT6) as PTM Enzyme



Substrate Site Score Source PMID
Q96LA8 (PRMT6) R29 UniProt 23866860
Q96LA8 (PRMT6) R35 UniProt 23866860
Q96LA8 (PRMT6) R37 UniProt 23866860


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R38 K38 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R38 M38 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y215 C215 Biomuta DOID:1319 / brain cancer [ cosmic ]
C221 Y221 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T227 M227 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]