iPTMnet Report for Q96IV0 (NGLY1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96IV0 / NGLY1_HUMAN
Protein Name Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Gene Name Name: NGLY1
Synonyms:PNG1;
Organism Homo sapiens (Human)

PRO ID PR:Q96IV0
DAG View
PRO Name peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (human)
Definition A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human.
Short Label hNGLY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96IV0 (NGLY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K50 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S116 O-Glycosylation GlyGen 30379171
S116 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus   UniProt 23186163
S177 Phosphorylation PhosphoSitePlus
K204 Methylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K210 Methylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
C359 Methylation IEDB 31844290
K394 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
T449 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K92 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S111 G111 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T137 P137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K419 Q419 Biomuta DOID:363 / uterine cancer [ icgc ]
K488 N488 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]