iPTMnet Report for Q96IV0 (NGLY1)
Protein Information
UniProt AC / UniProt ID | Q96IV0 / NGLY1_HUMAN |
Protein Name | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase |
Gene Name | Name: NGLY1 Synonyms:PNG1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96IV0 |
PRO Name | peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (human) |
Definition | A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human. |
Short Label | hNGLY1 |
Category | organism-gene |
Q96IV0 (NGLY1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330 | ||
K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
S110 | Phosphorylation | score1 | PhosphoSitePlus | |||
S111 | Phosphorylation | score1 | PhosphoSitePlus | |||
S116 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
S116 | Phosphorylation | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
T136 | Phosphorylation | score1 | PhosphoSitePlus | |||
T137 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
K204 | Methylation | score1 | PhosphoSitePlus | |||
K204 | Ubiquitination | score1 | PhosphoSitePlus | |||
K210 | Methylation | score1 | PhosphoSitePlus | |||
K210 | Ubiquitination | score1 | PhosphoSitePlus | |||
K272 | Ubiquitination | score1 | PhosphoSitePlus | |||
K276 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y295 | Phosphorylation | score1 | PhosphoSitePlus | |||
K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
C359 | Methylation | score1 | IEDB | 31844290 | ||
K394 | Ubiquitination | score1 | PhosphoSitePlus | |||
K406 | Ubiquitination | score1 | PhosphoSitePlus | |||
T413 | Phosphorylation | score1 | PhosphoSitePlus | |||
K419 | Ubiquitination | score1 | PhosphoSitePlus | |||
K448 | Ubiquitination | score1 | PhosphoSitePlus | |||
T449 | Phosphorylation | score1 | PhosphoSitePlus | |||
K451 | Ubiquitination | score1 | PhosphoSitePlus | |||
K477 | Ubiquitination | score1 | PhosphoSitePlus | |||
K488 | Ubiquitination | score1 | PhosphoSitePlus | |||
K501 | Ubiquitination | score1 | PhosphoSitePlus | |||
K584 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K92 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S111 | G111 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T137 | P137 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K419 | Q419 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K488 | N488 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |