iPTMnet Report for Q96GD4 (AURKB)
Protein Information
UniProt AC / UniProt ID | Q96GD4 / AURKB_HUMAN |
Protein Name | Aurora kinase B |
Gene Name | Name: AURKB Synonyms:AIK2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96GD4 |
PRO Name | aurora kinase B (human) |
Definition | An aurora kinase B that is encoded in the genome of human. |
Short Label | hAURKB |
Category | organism-gene |
Q96GD4 (AURKB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
S7 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22267324, 16565220 | ||
S7 | Phosphorylation | Q96GD4 (AURKB) | score1 | PhosphoSitePlus | 22267324 | |
Y8 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y12 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16565220 | ||
T16 | Phosphorylation | score1 | PhosphoSitePlus | 22267324 | ||
T16 | Phosphorylation | Q96GD4 (AURKB) | score1 | PhosphoSitePlus | 22267324 | |
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
T35 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
S61 | Phosphorylation | score1 | PhosphoSitePlus | |||
S62 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
T64 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
T73 | Phosphorylation | score1 | PhosphoSitePlus | |||
K85 | Sumoylation | score1 | PhosphoSitePlus | |||
K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
K87 | Sumoylation | score1 | PhosphoSitePlus | |||
K87 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y92 | Phosphorylation | score1 | PhosphoSitePlus | |||
K98 | Ubiquitination | score1 | PhosphoSitePlus | |||
K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
R147 | Methylation | score1 | PhosphoSitePlus | |||
K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
C170 | Methylation | score1 | IEDB | 31844290 | ||
T179 | Phosphorylation | score0 | RLIMS-P | 22024163 | ||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
K202 | Sumoylation | score2 | PRO PhosphoSitePlus | |||
K202 | Ubiquitination | score1 | PhosphoSitePlus | |||
K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
K215 | Acetylation | score3 | PhosphoSitePlus UniProt | 26829474 | ||
K215 | Ubiquitination | score1 | PhosphoSitePlus | |||
S227 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 28004745, 23186163, 34143863, ... | ||
K231 | Ubiquitination | score1 | PhosphoSitePlus | |||
T232 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt | 26369427, 25892238, 24344188, ... | ||
T232 | Phosphorylation | O14965 (AURKA) | score2 | RLIMS-P+ | 26369427 | |
T232 | Phosphorylation | Q13043 (STK4) | score2 | PhosphoSitePlus | 20171103 | |
T232 | Phosphorylation | Q96GD4 (AURKB) | score4 | neXtProt PhosphoSitePlus Signor UniProt | 14722118, 18767990, 22904328 | |
T236 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18220336 | ||
Y239 | Phosphorylation | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
K291 | Ubiquitination | score1 | PhosphoSitePlus | |||
K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
S313 | Phosphorylation | score1 | PhosphoSitePlus | |||
S331 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P Signor | 27126587, 17276342, 22024163, ... | ||
S331 | Phosphorylation | O14757 (CHEK1) | score4 | PhosphoSitePlus Signor | 17276342, 22024163 | |
S331 | Phosphorylation | PR:O14757 (hCHEK1) | score3 | PRO | 17276342, 22024163, 23321637 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S7 | Phosphorylation | score0 | HPRD | 18691976, 16565220, 19691289, ... | ||
Y12 | Phosphorylation | score0 | HPRD | 16565220 | ||
T16 | Phosphorylation | score0 | HPRD | 19007248 | ||
T35 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 19007248 | ||
S45 | Phosphorylation | score0 | HPRD | 18691976, 19007248, 19691289 | ||
S61 | Phosphorylation | score0 | HPRD | 18691976, 19007248, 20068231, ... | ||
S62 | Phosphorylation | score0 | HPRD | 19007248, 20068231, 19691289 | ||
T64 | Phosphorylation | score0 | HPRD | 18691976, 19007248, 20068231, ... | ||
Y92 | Phosphorylation | score0 | HPRD | 18691976 | ||
S227 | Phosphorylation | score0 | HPRD | 18691976 | ||
T232 | Phosphorylation | score0 | HPRD | 18691976, 20068231, 16565220 | ||
T236 | Phosphorylation | score0 | HPRD | 18691976 | ||
S313 | Phosphorylation | score0 | HPRD | 18691976 |
Q96GD4 (AURKB) as PTM Enzyme
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000035663 (hAURKB/Phos:1) | pS331 | PR:O14757 (hCHEK1) | PRO | 17276342, 22024163, 22024163, ... | |
PR:000046440 (hAURKB/Sumo:1) | suK202 | PRO |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000035661 (hAURKB/PhosRes-) | Interaction | PR:Q9NQS7 (hINCENP) | PRO | 22024163 | |
PR:000035663 (hAURKB/Phos:1) | Interaction | PR:Q9NQS7 (hINCENP) | PRO | 22024163 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q96GD4 (hAURKB) | PRO | ||
PR:P49450 (hCENPA) | Interaction | PR:Q96GD4 (hAURKB) | PRO | ||
PR:Q13043 (hSTK4) | Interaction | PR:Q96GD4 (hAURKB) | PRO | 20171103 | |
PR:Q15208 (hSTK38) | Interaction | PR:Q96GD4 (hAURKB) | PRO | 20171103 | |
PR:Q53HL2 (hCDCA8) | Interaction | PR:Q96GD4 (hAURKB) | PRO | ||
PR:Q5FBB7 (hSGO1) | Interaction | PR:Q96GD4 (hAURKB) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:O15392 (hBIRC5) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:P06493 (hCDK1) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:Q13043 (hSTK4) | PRO | 20171103 | |
PR:Q96GD4 (hAURKB) | Interaction | PR:Q71DI3 (hH3.2) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:Q12834 (hCDC20) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:P68431 (hH3.1) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:Q53HL2 (hCDCA8) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:Q9NQS7 (hINCENP) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:Q15208 (hSTK38) | PRO | 20171103 | |
PR:Q96GD4 (hAURKB) | Interaction | PR:O60566 (hBUB1B) | PRO | ||
PR:Q9NQS7 (hINCENP) | Interaction | PR:Q96GD4 (hAURKB) | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S45 | P45 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
K56 | N56 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K85 | T85 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
Y92 | D92 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K115 | N115 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
R147 | W147 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K164 | N164 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T179 | M179 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K194 | N194 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K211 | N211 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S313 | L313 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] |