Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96GD4 / AURKB_HUMAN
Protein Name Aurora kinase B
Gene Name Name: AURKB
Synonyms:AIK2,AIM1,AIRK2,ARK2,STK1,STK12,STK5;
Organism Homo sapiens (Human)

PRO ID PR:Q96GD4
DAG View
PRO Name aurora kinase B (human)
Definition An aurora kinase B that is encoded in the genome of human.
Short Label hAURKB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96GD4 (AURKB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
S7 Phosphorylation Q96GD4 (AURKB) phospho.ELM   PhosphoSitePlus 22267324, 16565220
Y8 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
T16 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
S19 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T35 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S45 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus   UniProt 20068231
T64 Phosphorylation PhosphoSitePlus   UniProt 20068231
T73 Phosphorylation PhosphoSitePlus
K85 Sumoylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
R147 Methylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T179 Phosphorylation RLIMS-P 22024163
K194 Ubiquitination PhosphoSitePlus
K202 Sumoylation PRO   PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 28004745
K231 Ubiquitination PhosphoSitePlus
T232 Phosphorylation O14965 (AURKA) , Q96GD4 (AURKB) , Q13043 (STK4) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26369427, 25892238, 24344188, ...28821562, 26829474, 29129699, 29568394, 14722118, 22990868, 27074040, 30728112, 26460953, 18220336, 27009191, 23071152, 22801782, 23707920, 20921135, 22024163, 18767990, 23615399, 28751710, 28004745, 22904328, 25885472, 20171103
T236 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y239 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S331 Phosphorylation O14757 (CHEK1) , PR:O14757 (hCHEK1) PRO   PhosphoSitePlus   RLIMS-P   Signor 27126587, 17276342, 22024163, ...23321637, 24344188
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18691976, 16565220, 19691289, ...19007248
Y12 Phosphorylation HPRD 16565220
T16 Phosphorylation HPRD 19007248
T35 Phosphorylation HPRD 18691976, 18669648, 19007248
S45 Phosphorylation HPRD 18691976, 19007248, 19691289
S61 Phosphorylation HPRD 18691976, 19007248, 20068231, ...19691289
S62 Phosphorylation HPRD 19007248, 20068231, 19691289
T64 Phosphorylation HPRD 18691976, 19007248, 20068231, ...19691289
Y92 Phosphorylation HPRD 18691976
S227 Phosphorylation HPRD 18691976
T232 Phosphorylation HPRD 18691976, 20068231, 16565220
T236 Phosphorylation HPRD 18691976
S313 Phosphorylation HPRD 18691976


Q96GD4 (AURKB) as PTM Enzyme



Substrate Site Score Source PMID
O00566 (MPHOSPH10) T332 PhosphoSitePlus 22267324
O00571 (DDX3X) S594 PhosphoSitePlus 22267324
O14777 (NDC80) S5 PhosphoSitePlus   Signor 20471944, 17129782
O14777 (NDC80) S15 PhosphoSitePlus   Signor 20471944, 17129782
O14777 (NDC80) S44 Signor 20471944
O14777 (NDC80) T49 PhosphoSitePlus 17129782
O14777 (NDC80) S55 PhosphoSitePlus 25987563, 17129782
O14777 (NDC80) S69 PhosphoSitePlus 17129782
O14950 (MYL12B) S20 PhosphoSitePlus 15676024
O15392 (BIRC5) T34 PhosphoSitePlus 24478433
O15392 (BIRC5) T117 neXtProt   PhosphoSitePlus   Signor 17457057, 14610074
O60879 (DIAPH2) S196 Signor 21397845
O95235 (KIF20A) S878 RLIMS-P+ 27939310
O95239 (KIF4A) T799 PhosphoSitePlus 23940115
P04637 (TP53) S183 neXtProt   PhosphoSitePlus   Signor 22611192, 20959462
P04637 (TP53) T211 neXtProt   PhosphoSitePlus   Signor 22611192
P04637 (TP53) S215 neXtProt   PhosphoSitePlus   Signor 22611192
P04637 (TP53) S269 PhosphoSitePlus   Signor 20959462
P04637 (TP53) T284 PhosphoSitePlus   Signor 20959462
P05204 (HMGN2) S25 PhosphoSitePlus 22267324
P05204 (HMGN2) S29 PhosphoSitePlus 22267324
P05787 (KRT8) T6 PhosphoSitePlus 22267324
P06400 (RB1) S780 neXtProt   PhosphoSitePlus 19225156
P08238 (HSP90AB1) S255 PhosphoSitePlus 22267324
P08238 (HSP90AB1) S452 PhosphoSitePlus 22267324
P08670 (VIM) S7 neXtProt 12458200
P08670 (VIM) S25 neXtProt 12458200
P08670 (VIM) S39 neXtProt 12458200
P08670 (VIM) S47 neXtProt 12458200
P08670 (VIM) S65 neXtProt 12458200
P08670 (VIM) S66 neXtProt 12458200
P08670 (VIM) S72 neXtProt 12458200
P08670 (VIM) S73 PhosphoSitePlus   Signor 14722118, 12458200, 15676024
P08670 (VIM) S87 neXtProt 12458200
P10412 (H1-4) S27 RLIMS-P+ 21511733
P14136 (GFAP) T7 neXtProt   PhosphoSitePlus 12686604
P14136 (GFAP) S13 neXtProt   PhosphoSitePlus 12686604
P14136 (GFAP) S38 neXtProt   PhosphoSitePlus 12686604
P14618 (PKM) T45 RLIMS-P+ 25412762
P17661 (DES) S12 HPRD   neXtProt   PhosphoSitePlus 12686604
P17661 (DES) T17 neXtProt   PhosphoSitePlus 12686604
P17661 (DES) S60 HPRD   neXtProt   PhosphoSitePlus 12686604
P18615 (NELFE) S131 PhosphoSitePlus 22267324
P25490 (YY1) S180 Signor 23226345
P25490 (YY1) S184 PhosphoSitePlus   Signor 23226345
P35659 (DEK) T67 PhosphoSitePlus 22267324
P38159 (RBMX) S326 PhosphoSitePlus 22267324
P45973 (CBX5) S92 PhosphoSitePlus 22267324
P46013 (MKI67) S374 PhosphoSitePlus 22267324
P46013 (MKI67) S538 PhosphoSitePlus 22267324
P46778 (RPL21) S104 PhosphoSitePlus 22267324
P46783 (RPS10) T118 PhosphoSitePlus 22267324
P49450 (CENPA) S7 HPRD   neXtProt   PhosphoSitePlus   Signor 11756469
P53350 (PLK1) T210 PhosphoSitePlus 26206521
P56524 (HDAC4) S265 neXtProt   Signor 22865920
P62917 (RPL8) S130 PhosphoSitePlus 22267324
P68431 (H3C12) S11 Signor 12588998, 14583461
P68431 (H3C12) S29 Signor 11856369, 21282660
P78527 (PRKDC) S511 PhosphoSitePlus 22267324
P82970 (HMGN5) S20 PhosphoSitePlus 22267324
P82970 (HMGN5) S24 PhosphoSitePlus 22267324
P84243 (H3-3B) S11 Signor 12588998, 10464286, 14583461
P98179 (RBM3) S147 PhosphoSitePlus 22267324
Q02224 (CENPE) T422 neXtProt 20691903
Q02241-2 (KIF23) S708 PhosphoSitePlus 20451386
Q02241 (KIF23) S911 PhosphoSitePlus 16461284, 19203582
Q08J23 (NSUN2) S139 HPRD   neXtProt   PhosphoSitePlus   Signor 17215513
Q09666 (AHNAK) T158 PhosphoSitePlus 22267324
Q13315 (ATM) S1403 neXtProt   PhosphoSitePlus   Signor 22099307
Q14980 (NUMA1) T1811 PhosphoSitePlus 22267324
Q14980 (NUMA1) S1969 PhosphoSitePlus 22267324
Q14980 (NUMA1) S2047 PhosphoSitePlus 22267324
Q14980 (NUMA1) T2055 PhosphoSitePlus 22267324
Q15149 (PLEC) T2886 PhosphoSitePlus 22267324
Q17R91 (DIAPH2) T66 PhosphoSitePlus 21397845
Q17R91 (DIAPH2) S196 PhosphoSitePlus 21397845
Q17R91 (DIAPH2) S820 PhosphoSitePlus 21397845
Q17R91 (DIAPH2) T882 PhosphoSitePlus 21397845
Q3KR16 (PLEKHG6) T544 Signor 24482237
Q53HL2 (CDCA8) S154 neXtProt   PhosphoSitePlus 17483322
Q53HL2 (CDCA8) S165 PhosphoSitePlus 15249581
Q53HL2 (CDCA8) S219 neXtProt   PhosphoSitePlus 17483322
Q53HL2 (CDCA8) S275 neXtProt   PhosphoSitePlus 17483322
Q53HL2 (CDCA8) T278 neXtProt   PhosphoSitePlus 17483322
Q5UIP0 (RIF1) S2205 PhosphoSitePlus 22267324
Q69YH5 (CDCA2) S893 PhosphoSitePlus 23746640
Q6NZI2 (CAVIN1) S300 PhosphoSitePlus 22267324
Q8IVT2 (MISP) S348 PhosphoSitePlus 22267324
Q8IX03 (WWC1) S539 PhosphoSitePlus   Signor 21878642
Q8IX90 (SKA3) S159 neXtProt 22371557
Q8NEM2 (SHCBP1) S634 PhosphoSitePlus 23704356
Q8NEY8 (PPHLN1) S110 PhosphoSitePlus 22267324
Q8NG31 (KNL1) S24 PhosphoSitePlus   Signor 20471944
Q8NG31 (KNL1) S60 PhosphoSitePlus   Signor 20471944
Q8TE77 (SSH3) S37 PhosphoSitePlus 22267324
Q8TEW0 (PARD3) S962 PhosphoSitePlus 19812038
Q8TF76 (HASPIN) S93 neXtProt 21658950
Q8TF76 (HASPIN) S143 neXtProt 21658950
Q8WWI1 (LMO7) S300 PhosphoSitePlus 22267324
Q8WWI1 (LMO7) S751 PhosphoSitePlus 22267324
Q8WWK9 (CKAP2) S628 PhosphoSitePlus   Signor 20458174
Q8WYJ6 (SEPTIN1) S248 PhosphoSitePlus 16179162
Q8WYJ6 (SEPTIN1) S307 PhosphoSitePlus 16179162
Q8WYJ6 (SEPTIN1) S315 PhosphoSitePlus 16179162
Q96CF2 (CHMP4C) S210 neXtProt   PhosphoSitePlus   Signor 22724069, 22422861
Q96CF2 (CHMP4C) S214 PhosphoSitePlus   Signor 22724069
Q96CF2 (CHMP4C) S215 PhosphoSitePlus   Signor 22724069, 22422861
Q96FF9 (CDCA5) S33 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) S79 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) S83 PhosphoSitePlus 22267324, 23901111
Q96FF9 (CDCA5) T111 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) T115 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) S126 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) S139 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) T151 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) T159 PhosphoSitePlus 23901111
Q96FF9 (CDCA5) S164 PhosphoSitePlus 23901111
Q96GD4 (AURKB) S7 PhosphoSitePlus 22267324
Q96GD4 (AURKB) T16 PhosphoSitePlus 22267324
Q96GD4 (AURKB) T232 neXtProt   PhosphoSitePlus   Signor   UniProt 14722118, 18767990, 22904328
Q96PK6 (RBM14) S649 PhosphoSitePlus 22267324
Q99661 (KIF2C) S95 neXtProt   PhosphoSitePlus   Signor 17567953, 14960279
Q99661 (KIF2C) S109 PhosphoSitePlus 14960279
Q99661 (KIF2C) S111 PhosphoSitePlus   Signor 17567953, 14960279
Q99661 (KIF2C) S115 PhosphoSitePlus 14960279
Q99661 (KIF2C) S192 neXtProt   PhosphoSitePlus   Signor 17567953, 14960279
Q9BQG0 (MYBBP1A) S1303 PhosphoSitePlus   Signor 22267324, 20177074
Q9BW61 (DDA1) S33 PhosphoSitePlus 22267324
Q9BXS6 (NUSAP1) S240 PhosphoSitePlus 22267324
Q9H0H5 (RACGAP1) S144 HPRD   Signor 18669648, 14744859, 19007248
Q9H0H5 (RACGAP1) T145 HPRD   Signor 14744859, 19007248
Q9H0H5 (RACGAP1) S185 HPRD   Signor 14744859, 17287340
Q9H0H5 (RACGAP1) T186 HPRD   Signor 14744859
Q9H0H5 (RACGAP1) S187 HPRD   Signor 17287340, 14744859
Q9H0H5 (RACGAP1) T249 PhosphoSitePlus 22267324
Q9H0H5 (RACGAP1) S387 HPRD   PhosphoSitePlus   Signor 12689593
Q9H0H5 (RACGAP1) S410 HPRD 12689593
Q9H410 (DSN1) S100 PhosphoSitePlus   Signor 18640974, 20471944
Q9H410 (DSN1) S109 PhosphoSitePlus   Signor 18640974, 20471944
Q9H6F5 (CCDC86) S255 PhosphoSitePlus 22267324
Q9H788 (SH2D4A) S261 PhosphoSitePlus 22267324
Q9NP77 (SSU72) S19 PhosphoSitePlus 24149858
Q9NQS7 (INCENP) T59 PhosphoSitePlus 22267324
Q9NQS7 (INCENP) S72 PhosphoSitePlus 22267324
Q9NQS7 (INCENP) T494 PhosphoSitePlus 22267324
Q9NQS7 (INCENP) S518 PhosphoSitePlus 22267324
Q9NQS7-2 (INCENP) T888 HPRD 12925766, 18691976, 18669648, ...20068231
Q9NQS7-2 (INCENP) S889 HPRD 12925766, 18691976, 18669648
Q9NQS7-2 (INCENP) S890 HPRD 12925766, 18691976, 18669648, ...16565220
Q9NQS7 (INCENP) T892 PhosphoSitePlus   Signor 12925766
Q9NQS7 (INCENP) S893 PhosphoSitePlus   Signor 12925766, 18767990
Q9NQS7 (INCENP) S894 PhosphoSitePlus   Signor 12925766, 18767990
Q9NQS7 (INCENP) S899 PhosphoSitePlus 22267324
Q9NQZ2 (UTP3) S462 PhosphoSitePlus 22267324
Q9NS23-2 (RASSF1) S203 PhosphoSitePlus 19276349
Q9NS23 (RASSF1) S207 Signor 19276349
Q9UBB4 (ATXN10) S12 PhosphoSitePlus 25666058
Q9UJ70 (NAGK) S76 PhosphoSitePlus 22267324
Q9UKV0 (HDAC9) S239 neXtProt   Signor 22865920
Q9UPY8 (MAPRE3) S176 PhosphoSitePlus   Signor 19696028, 23712260
Q9UQL6 (HDAC5) S278 neXtProt   PhosphoSitePlus   Signor 22865920
Q9Y2I6 (NINL) S185 PhosphoSitePlus   Signor 20864540
Q9Y2I6 (NINL) S448 PhosphoSitePlus   Signor 20864540
Q9Y2I6 (NINL) S585 PhosphoSitePlus   Signor 20864540
Q9Y2R4 (DDX52) S22 PhosphoSitePlus 22267324
Q9Y5B9 (SUPT16H) T494 PhosphoSitePlus 22267324


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035663 (hAURKB/Phos:1) pS331 PR:O14757 (hCHEK1) PRO 17276342, 22024163, 22024163, ...23321637
PR:000046440 (hAURKB/Sumo:1) suK202 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y2I6 (NINL) S448 Q96GD4 (AURKB) unknown eFIP 21505454


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035661 (hAURKB/PhosRes-) Interaction PR:Q9NQS7 (hINCENP) PRO 22024163
PR:000035663 (hAURKB/Phos:1) Interaction PR:Q9NQS7 (hINCENP) PRO 22024163
PR:O60566 (hBUB1B) Interaction PR:Q96GD4 (hAURKB) PRO
PR:P49450 (hCENPA) Interaction PR:Q96GD4 (hAURKB) PRO
PR:Q13043 (hSTK4) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q15208 (hSTK38) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q53HL2 (hCDCA8) Interaction PR:Q96GD4 (hAURKB) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:Q96GD4 (hAURKB) PRO
PR:Q96GD4 (hAURKB) Interaction PR:Q53HL2 (hCDCA8) PRO
PR:Q96GD4 (hAURKB) Interaction PR:P68431 (hH3.1) PRO
PR:Q96GD4 (hAURKB) Interaction PR:Q15208 (hSTK38) PRO 20171103
PR:Q96GD4 (hAURKB) Interaction PR:O60566 (hBUB1B) PRO
PR:Q96GD4 (hAURKB) Interaction PR:O15392 (hBIRC5) PRO
PR:Q96GD4 (hAURKB) Interaction PR:Q9NQS7 (hINCENP) PRO
PR:Q96GD4 (hAURKB) Interaction PR:Q13043 (hSTK4) PRO 20171103
PR:Q96GD4 (hAURKB) Interaction PR:Q71DI3 (hH3.2) PRO
PR:Q96GD4 (hAURKB) Interaction PR:Q12834 (hCDC20) PRO
PR:Q96GD4 (hAURKB) Interaction PR:P06493 (hCDK1) PRO
PR:Q9NQS7 (hINCENP) Interaction PR:Q96GD4 (hAURKB) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T16 K16 Biomuta DOID:3571 / liver cancer [ icgc ]
S45 P45 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K56 N56 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K85 T85 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T179 M179 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K211 N211 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S313 L313 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ tcga ]