iPTMnet Report for Q96FV9 (THOC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96FV9 / THOC1_HUMAN
Protein Name THO complex subunit 1
Gene Name Name: THOC1
Synonyms:HPR1;
Organism Homo sapiens (Human)

PRO ID PR:Q96FV9
DAG View
PRO Name THO complex subunit 1 (human)
Definition A THO complex subunit 1 that is encoded in the genome of human.
Short Label hTHOC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96FV9 (THOC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
T4 Phosphorylation PhosphoSitePlus   UniProt 23186163
T15 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
K31 Sumoylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus   UniProt 19608861
K237 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K300 Acetylation PhosphoSitePlus   UniProt 19608861
S313 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K408 Sumoylation PhosphoSitePlus
K425 Methylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
Y521 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 23186163
T542 Phosphorylation PhosphoSitePlus   UniProt 23186163
S560 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 17081983, ...20068231
K580 Ubiquitination PhosphoSitePlus
K595 Sumoylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 18669648, 20068231
T4 Phosphorylation HPRD 20068231
T439 Phosphorylation HPRD 20068231
S560 Phosphorylation HPRD 15302935, 20068231, 18452278
S657 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 K4 Biomuta DOID:3571 / liver cancer [ cosmic ]
K376 E376 Biomuta DOID:1319 / brain cancer [ cosmic, icgc, tcga ]
K425 E425 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K430 N430 Biomuta DOID:363 / uterine cancer [ icgc ]