iPTMnet Report for Q96EA4 (SPDL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96EA4 / SPDLY_HUMAN
Protein Name Protein Spindly
Gene Name Name: SPDL1
Synonyms:CCDC99;
Organism Homo sapiens (Human)

PRO ID PR:Q96EA4
DAG View
PRO Name protein Spindly (human)
Definition A protein Spindly that is encoded in the genome of human.
Short Label hSPDL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96EA4 (SPDL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
C11 Methylation IEDB 31844290
S145 Phosphorylation PhosphoSitePlus
R154 Methylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
C416 Methylation IEDB 31844290
T461 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
T487 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S493 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S513 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 23186163, 20068231
S515 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18847512, 23186163, 17081983, ...20068231
S546 Phosphorylation PhosphoSitePlus
S555 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 35093072, 17287340
S562 Phosphorylation PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T487 Phosphorylation HPRD 17525332
S504 Phosphorylation HPRD 20068231
S506 Phosphorylation HPRD 20068231
Y508 Phosphorylation HPRD 20068231
T509 Phosphorylation HPRD 20068231
S513 Phosphorylation HPRD 20068231
S555 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R154 H154 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y347 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S471 R471 Biomuta DOID:3571 / liver cancer [ cosmic ]
S493 R493 Biomuta DOID:363 / uterine cancer [ icgc ]
S506 F506 Biomuta DOID:4159 / skin cancer [ cosmic ]
S515 C515 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S594 T594 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T600 A600 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]