iPTMnet Report for Q96EA4 (SPDL1)
Protein Information
| UniProt AC / UniProt ID | Q96EA4 / SPDLY_HUMAN |
| Protein Name | Protein Spindly |
| Gene Name | Name: SPDL1 Synonyms:CCDC99; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96EA4 |
| PRO Name | protein Spindly (human) |
| Definition | A protein Spindly that is encoded in the genome of human. |
| Short Label | hSPDL1 |
| Category | organism-gene |
DAG ViewQ96EA4 (SPDL1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| C11 | Methylation | score1 | IEDB | 31844290 | ||
| S145 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R154 | Methylation | score1 | PhosphoSitePlus | |||
| K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K331 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y347 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y366 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C416 | Methylation | score1 | IEDB | 31844290 | ||
| T461 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S471 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T487 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
| S493 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T509 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S513 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18847512, 23186163, 20068231 | ||
| S513 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
| S515 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18847512, 23186163, 17081983, ... | ||
| S515 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
| S546 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S555 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 35093072, 17287340 | ||
| S562 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T566 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S594 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T600 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T487 | Phosphorylation | score0 | HPRD | 17525332 | ||
| S504 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S506 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y508 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T509 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S513 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S555 | Phosphorylation | score0 | HPRD | 17287340 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R154 | H154 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y347 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S471 | R471 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S493 | R493 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S506 | F506 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S515 | C515 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S594 | T594 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T600 | A600 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] |
