iPTMnet Report Q96BR1 SGK3

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96BR1 / SGK3_HUMAN
Protein Name	Serine/threonine-protein kinase Sgk3
Gene Name	Name: SGK3 Synonyms:CISK,SGKL;
Organism	Homo sapiens (Human)

PRO ID	PR:Q96BR1 DAG View
PRO Name	serine/threonine-protein kinase Sgk3 (human)
Definition	A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human.
Short Label	hSGK3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96BR1 (SGK3) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T32	Phosphorylation		score1	PhosphoSitePlus
	K75	Methylation		score1	PhosphoSitePlus
	S121	Phosphorylation		score1	PhosphoSitePlus
	S126	Phosphorylation		score1	PhosphoSitePlus
	S129	Phosphorylation		score1	PhosphoSitePlus
	K139	Ubiquitination		score1	PhosphoSitePlus
	K158	Ubiquitination		score1	PhosphoSitePlus
	K166	Ubiquitination		score1	PhosphoSitePlus
	Y188	Phosphorylation		score1	PhosphoSitePlus
	K191	Ubiquitination		score1	PhosphoSitePlus
	K216	Ubiquitination		score1	PhosphoSitePlus
	S315	Phosphorylation		score1	PhosphoSitePlus
	T318	Phosphorylation		score1	PhosphoSitePlus
	T320	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	29940988, 27481935, 26573229, ...16790420, 25177796, 33618712, 10548550
	T320	Phosphorylation	O15530 (PDPK1)	score4	PhosphoSitePlus Signor	10548550, 16790420
	T324	Phosphorylation		score1	PhosphoSitePlus
	K407	Ubiquitination		score1	PhosphoSitePlus
	S486	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	16888620, 14604990, 25177796, ...16790420

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T320	Phosphorylation		score1	HPRD	10548550
	T320	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550
	S486	Phosphorylation		score1	HPRD	10548550
	S486	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T320	Phosphorylation		score1	HPRD	10548550
	T320	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550
	S454	Phosphorylation		score1	HPRD	10548550
	S454	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550

Q96BR1 (SGK3) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O43524 (FOXO3)	S253	score1	Signor	11154281
	P49840 (GSK3A)	S21	score3	HPRD Signor	11884598, 16543730, 12054501, ...18691976, 11749387, 19413330, 11035810
	P49841-2 (GSK3B)	S9	score4	HPRD neXtProt PhosphoSitePlus Signor	18691976, 18669648, 12054501, ...16543730
	P49841-2 (GSK3B)	S21	score2	HPRD	18691976, 12054501
	Q13045 (FLII)	S436	score3	neXtProt PhosphoSitePlus Signor	19293151
	Q13045 (FLII)	T818	score3	neXtProt PhosphoSitePlus Signor	19293151
	Q96J02 (ITCH)	T385	score2	PhosphoSitePlus	16888620
	Q96J02 (ITCH)	S450	score2	PhosphoSitePlus	16888620
	Q96PU5 (NEDD4L)	S448	score3	neXtProt	15044175, 15496163

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S121	G121	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ]
K158	E158	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
K191	E191	Biomuta		DOID:263 / kidney cancer [ cosmic ]
T318	N318	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]