Protein Information

Cytoscape View

UniProt AC / UniProt ID Q96BK5 / PINX1_HUMAN
Protein Name PIN2/TERF1-interacting telomerase inhibitor 1
Gene Name Name: PINX1
Organism Homo sapiens (Human)

DAG View
PRO Name PIN2/TERF1-interacting telomerase inhibitor 1 (human)
Definition A pin2-interacting protein X1 that is encoded in the genome of human.
Short Label hPINX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q96BK5 (PINX1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S110 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20573420
S117 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20573420
Y126 Phosphorylation PhosphoSitePlus
T141 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20573420
S161 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S163 Phosphorylation PhosphoSitePlus
T164 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T170 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T171 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S226 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20573420
Y227 Phosphorylation PhosphoSitePlus
K231 Sumoylation PhosphoSitePlus
K252 Methylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
T317 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20573420
Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation HPRD 18669648
T164 Phosphorylation HPRD 18669648
T170 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R7 P7 Biomuta DOID:1324 / lung cancer [ tcga ]
S110 Y110 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S161 R161 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
T170 N170 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K252 N252 Biomuta DOID:1909 / melanoma [ cosmic ]
T317 M317 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]