iPTMnet Report Q93099 HGD

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q93099 / HGD_HUMAN
Protein Name	Homogentisate 1,2-dioxygenase
Gene Name	Name: HGD Synonyms:HGO;
Organism	Homo sapiens (Human)

PRO ID	PR:Q93099 DAG View
PRO Name	homogentisate 1,2-dioxygenase (human)
Definition	A homogentisate 1,2-dioxygenase that is encoded in the genome of human.
Short Label	hHGD
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q93099 (HGD) as Substrate

Q93099

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y40	Phosphorylation		score1	PhosphoSitePlus
	K98	Acetylation		score2	PhosphoSitePlus UniProt	19608861
	Y166	Phosphorylation		score1	PhosphoSitePlus
	T167	Phosphorylation		score1	PhosphoSitePlus
	T244	Phosphorylation		score1	PhosphoSitePlus
	Y249	Phosphorylation		score1	PhosphoSitePlus
	S296	Phosphorylation		score2	HPRD PhosphoSitePlus	19664995
	T302	Phosphorylation		score2	HPRD PhosphoSitePlus	19664995
	Y333	Phosphorylation		score1	PhosphoSitePlus
	Y334	Phosphorylation		score1	PhosphoSitePlus
	S416	O-Glycosylation		score1	GlyGen	30379171
	Y423	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y166	H166	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S296	F296	Biomuta		DOID:4159 / skin cancer [ cosmic ]
T302	N302	Biomuta		DOID:1324 / lung cancer [ cosmic ]